The purpose of these studies was to test whether 02 tension influences cardiotoxicity due to doxorubicin. Isolated hearts were perfused by the method of Langendorff at constant pressure with Krebs-Henseleit buffer saturated with 5% CO2 and either 95% or 20% 02. Toxicity due to doxorubicin was evaluated from changes in heart rate and from uptake of trypan blue by nonviable nuclei. Heart rate was...

Multiplex families with type 1 diabetes are important for identification of rare variants that cannot be identified in case-control association studies. The very low incidence of type 1 diabetes in the Japanese population, however, makes identification of such families difficult. We identified a Japanese family in which three members developed type 1 diabetes, and studied the genotype of the hu...

We examined the effect of HLA class I haplotypes on HIV-1 seroconversion and disease progression in the Pumwani sex worker cohort. This study included 595 HIV-1 positive patients and 176 HIV negative individuals. HLA-A, -B, and -C were typed to 4-digit resolution using sequence-based typing method. HLA class I haplotype frequencies were estimated using PyPop 32-0.6.0. The influence of haplotype...

Background Four previously published trials assessed the efficacy of MP29-02* (a novel intranasal formulation of azelastine hydrochloride (AZE) and fluticasone propionate (FP) in an advanced delivery system) in seasonal allergic rhinitis (SAR) [1,2]. The first study compared MP29-02* to marketed AZE and FP [2]. The others compared MP29-02* to AZE and FP in the MP29-02* vehicle and delivery devi...

data types; cf. Data encapsulation; Inheritance Administrative data processing; cf. Spreadsheet programs Algebraic specification dyn. model for OO modeling, formalization and integrat. Cheng, B.H.C., + , T-SE Aug 02 747-762 Application program interfaces config. mgt. policy prog. testbed. van der Hoek, A., + , T-SE Jan 02 79-99 dyn. real-time distributed systs. engng. Ravindran, B., T-SE Jan 02...

Study objectives: To investigate the etiology of posthyperventilation (post-HV) hypoxemia following voluntary hyperventilation (VHV), we examined the effects of hypocapnic (hypo-C02) and isocapnic (iso-C02) VHV on the hypoxic ventilatory response (02-response) and on the sensation of breathlessness during the 02-response. Methods: 02-responses and visual analog scale (VAS) scores for estimating...

data types geospatial data modeling, database perspective. Voisard, A., + , T-KDE Mar-Apr 02 226-243 Abstract data types; cf. Inheritance Active databases act. database trigger condition testing and view maint. using optimized discrim. networks. Hanson, E.N., + , T-KDE Mar-Apr 02 261-280 real-time act. database systs. concurrency control. Datta, A., + , T-KDE May-Jun 02 465-484 Administrative d...

In 40% of cases of classical Hodgkin lymphoma (cHL), Epstein-Barr virus (EBV) latency-II antigens [EBV nuclear antigen 1 (EBNA1)/latent membrane protein (LMP)1/LMP2A] are present (EBV(+) cHL) in the malignant cells and antigen presentation is intact. Previous studies have shown consistently that HLA-A*02 is protective in EBV(+) cHL, yet its role in disease pathogenesis is unknown. To explore th...