نتایج جستجو برای: کدهای mds
تعداد نتایج: 9245 فیلتر نتایج به سال:
Myelodysplastic syndromes (MDS) are a group of myeloid hematological malignancies, with a high risk of progression to acute myeloid leukemia (AML). To explore the role of acquired mutations in MDS, 111 MDS-associated genes were screened using next-generation sequencing (NGS), in 125 patients. One or more mutations were detected in 84% of the patients. Some gene mutations are specific for MDS an...
Maximum distance separable (MDS) matrices have applications not only in coding theory but are also of great importance in the design of block ciphers and hash functions. It is highly nontrivial to find MDS matrices which could be used in lightweight cryptography. In a SAC 2004 paper, Junod et. al. constructed a new class of efficient MDS matrices whose submatrices were circulant matrices and th...
In a previous study, we identified somatic mutations of SF3B1, a gene encoding a core component of RNA splicing machinery, in patients with myelodysplastic syndrome (MDS). Here, we define the clinical significance of these mutations in MDS and myelodysplastic/myeloproliferative neoplasms (MDS/MPN). The coding exons of SF3B1 were screened using massively parallel pyrosequencing in patients with ...
OBJECTIVES We retrospectively tested the prognostic and diagnostic significance of CD271+ mesenchymal stromal cell (MSC) density in cytopenic patients who underwent bone marrow biopsy to evaluate for myelodysplastic syndromes (MDS). METHODS CD271+ MSC density was quantitated by automated image analysis of tissue microarray cores in 125 cytopenic patients: 40 lower grade MDS (<5% marrow blasts...
Diagnosing a myelodysplastic syndrome (MDS) can be challenging. Somatic mutations are common in MDS and might have diagnostic utility in patients with idiopathic cytopenias of undetermined significance (ICUS). However, using mutations to diagnose MDS is complicated by several issues: (1) no gene is mutated in most cases, (2) no mutated gene is highly specific for MDS, (3) clonal hematopoiesis i...
We investigate on the localization of nodes in a sensor network based on multidimensional scaling (MDS). The distances of node pairs are given and MDS attempts to locate the position of nodes given the distance matrix. However, conventional MDS addresses the mapping problem using eigenvector decomposition which is complicated in computation, mitigating the efficiency of this approach for real...
Although aplastic anemia (AA) and myelodysplastic syndrome (MDS) are separate entities with different management, distinction between the two can be difficult on morphological basis due to hypocellularity of bone marrow. MDS is one of the serious complications of AA. Karyotyping is definitive in the diagnosis of MDS. Better and robust investigations like 18F-Fluoro-deoxy-Glucose Posi...
studies have shown that the percentage of ring sideroblasts in MDS is not prognostically important. Thus, in the revised WHO classification, a diagnosis of MDS-RS may be made even in the presence of only 5% of ring sideroblasts in cases with SF3B1 mutation. MDS-RS cases will be subdivided into cases with single lineage dysplasia (previously classified as RARS) and cases with multilineage dyspla...
We set a model to replicate the vascular bone marrow niche by using endothelial colony forming cells (ECFCs), and we used it to explore the vascular niche function in patients with low-risk myelodysplastic syndromes (MDS). Overall, we investigated 56 patients and we observed higher levels of ECFCs in MDS than in healthy controls; moreover, MDS ECFCs were found variably hypermethylated for p15IN...
Maximum-distance separable (MDS) convolutional codes are characterized through the property that the free distance attains the generalized singleton bound. The existence of MDS convolutional codes was established by two of the authors by using methods from algebraic geometry. This correspondence provides an elementary construction of MDS convolutional codes for each rate k/n and each degree δ. ...
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