The emergence of multidrug-resistant and extensively drug-resistant (XDR) tuberculosis (TB) is a serious global threat. Aminoglycoside antibiotics are used as a last resort to treat XDR-TB. Resistance to the aminoglycoside kanamycin is a hallmark of XDR-TB. Here, we reveal the function and structure of the mycobacterial protein Eis responsible for resistance to kanamycin in a significant fracti...

Executive information systems (EIS) are the most-recent computer-based information systems to have emerged with the intention of providing executives with the information they require to run their businesses. Some advocates of these systems see them as a panaceathe long-awaited moment when computing will provide meaningful and significant assistance to top management. However, others have ques...

Enterprise information systems (EIS) development raises specific challenges related to the scale and complexity of the business processes that must be supported. Techniques for managing the challenges of scale and complexity are often based on modelling, and are targeted at different parts of the EIS development process. This paper presents the results of an evaluation (based on EIS for health ...

We designed a novel 6-point electrochemical impedance spectroscopy (EIS) sensor with 15 combinations of permutations for the 3-D mapping and detection of metabolically active atherosclerotic lesions. Two rows of 3 stretchable electrodes circumferentially separated by 120° were mounted on an inflatable balloon for intravascular deployment and endoluminal interrogation. The configuration and 15 p...

OBJECTIVES Specialist early intervention services (EIS) for people aged 14-35 years with first episodes of psychosis (FEP) have been commissioned throughout England since 2001. A single estimate of population need was used everywhere, but true incidence varies enormously according to sociodemographic factors. We sought to develop a realistically complex, population-based prediction tool for FEP...