Dabigatran etexilate, a double prodrug of dabigatran, is a reversible, competitive, direct thrombin inhibitor that has been approved for use in many countries. A recent guideline from the European Medicines Agency on drug-drug interactions proposed dabigatran etexilate as a sensitive in vivo and in vitro probe substrate for intestinal P-glycoprotein (P-gp) inhibition. We therefore performed a s...

Solutions to Exercise Set #4 1. Optical communication channel. Let the signal input to an optical channel be given by X = 1 with probability 1 2 10 with probability 1 2. Find y * and the corresponding probability of error.

We describe our experience with collecting roughly 250, 000 image annotations on Amazon Mechanical Turk (AMT). The annotations we collected range from location of keypoints and figure ground masks of various object categories, 3D pose estimates of head and torsos of people in images and attributes like gender, race, type of hair, etc. We describe the setup and strategies we adopted to automatic...

Sudden cardiac death (SCD) remains a major public health problem. More than 250 000 deaths in the United States are attributed to SCD annually, and recent statistics demonstrate that in 1999, there were 341 780 cases of out-of-hospital cardiac arrest, accounting for 47% of all cardiac-related deaths.1 Despite improvements in emergency systems across the country and advances in the prevention an...

Electrodeposition experiments of the charge-transfer complex copper tetracyanoquinodimethane (CuTCNQ) (where TCNQ denotes 7,7',8,8'-tetracyanoquinodimethane) on noble metal electrodes (M=Pt and Au) were optimized in order to produce suitable layers for bipolar resistive switching cross-bar M/CuTCNQ/Al memory cells. Corresponding memories exhibited up to more than 10 000 consecutive write/erase ...

The World-Wide Molecular Matrix (WWMM) is a ten year project to create a peer-to-peer (P2P) system for the publication and collection of chemical objects, including over 250, 000 molecules. It has now been instantiated in a number of repositories which include data encoded in Chemical Markup Language (CML) and linked by URIs and RDF. The technical specification and implementation is now complet...

Pt/TiO2 sensitized by the cheap and organic ortho-dihydroxyl-9,10-anthraquinone dyes, such as Alizarin and Alizarin Red, achieved a TON of approximately 10 000 (TOF > 250 h(-1) for the first ten hours) during >80 hours of visible light irradiation (>420 nm) for photocatalytic hydrogen evolution when triethanolamine was used as the sacrificial donor. The stability and activity enhancements can b...

The spontaneous-emission branching fractions of 32 levels of Pr II were measured by the fast-ion-beam laser-induced-fluorescence technique. The levels studied had energies from ∼21 500 to ∼29 000 cm−1, and the decay branches detected were in the range from 250 to 850 nm. The experimental uncertainties are within 10%. Using our previously measured radiative lifetimes, we determined the Einstein ...

In 2002, over 110 000 people entered Britain to seek asylum—a 250% increase in five years. Children, who comprise at least a quarter of asylum seekers, are exposed to numerous risk factors for psychological disturbance, including exposure to violence, forced displacement, and multiple losses. 2 The rates of mental health problems in refugee children are uncertain, but the few studies that have ...