Chemoprevention is a practical approach to control colorectal cancer, which is one of the major causes of cancer mortality in the United States. Based on our recent silibinin efficacy studies in human colorectal cancer cells, we investigated the effects of its dietary feeding on azoxymethane (AOM)-induced aberrant crypt foci (ACF) formation and associated biomarkers in male Fisher 344 rats. Fiv...

A systematic analysis is performed on the e ectiveness of removing degrees of freedom from hydrogen atoms and/or increasing hydrogen masses to increase the e ciency of molecular dynamics simulations of hydrogen-rich systems such as proteins in water. In proteins, high-frequency bond-angle vibrations involving hydrogen atoms limit the time step to 3 fs, which is already a factor of 1.5 beyond th...

I first summarize Baltag and Smets’ contribution to this volume, and praise their work. Then I compare the anti-lexicographic plausibility update that they propose to a proposal by Aucher, as an illustration of the difference between a qualitative and a quantitive formulation of updates. I quote Spohn’s original work that is at the root of research in plausibility updates and of the notion of a...

Pyruvate dehydrogenase (PDH) plays a key role in the regulation of skeletal muscle substrate utilization. IL-6 is produced in skeletal muscle during exercise in a duration dependent manner and has been reported to increase whole body fatty acid oxidation, muscle glucose uptake and decrease PDHa activity in skeletal muscle of fed mice. The aim of the present study was to examine whether muscle I...