BACKGROUND Etanercept plus methotrexate combination therapy has not been adequately investigated in psoriasis. OBJECTIVES To evaluate etanercept plus methotrexate vs. etanercept monotherapy in patients with moderate to severe plaque psoriasis who had not failed prior methotrexate or tumour necrosis factor-inhibitor therapy. METHODS Patients received etanercept 50 mg twice weekly for 12 week...

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Objective: This work aims to evaluate whether glaucomatous visual ®eld defects could be related to an impaired retinal function, to a delayed neural conduction in postretinal visual pathways, or both. Methods: Visual ®eld by Humphrey perimeter (central 24-2 threshold test) and simultaneous recordings of visual evoked potential (VEP) and pattern electroretinogram (PERG) were assessed in 21 subje...

Purpose – The purpose of this paper is to explore the relationship between transformational leadership and a transactional leadership component (management by exception-active), and fulfillment of the basic needs of autonomy, competence and relatedness. Design/methodology/approach – The paper is based on cross sectional data from 661 employees who completed validated questionnaires such as the ...

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Results from a pilot project indicate that isoflavones and exercise could have an additive effect on body composition and clinical risk factors of CVD in postmenopausal women. The objective of the present study was to assess the combined effect of exercise and isoflavones in overweight-to-obese postmenopausal women. In this double-blind randomised controlled trial, 100 overweight-to-obese (BMI ...

was 17-9 + 1-4 mg (M ± SEM) compared with 27 ± 5-4 mg in controls (p < 0 01). Dose correlated significantly with serum albumin (p < 0-05). Baseline mean dominant frequency (MDF) and slow wave index (SWI) significantly correlated with albumin (p < 0 01). After diazepam, the MDF decreased and SWI increased. The change was greatest at the time of maximal clinical response. It was greater in liver ...

A trial was conducted to evaluate the ability of a prostaglandin analog, Luprostiol (LP), to synchronize estrus in Brahman cows and heifers. Animals were injected with either 0, 3.75, 7.5, 15 or 30 mg LP or 500 micrograms cloprostenol (CLP) on d 8 or 9 after estrus (d 0). All concentrations of LP (greater than 0 mg) and CLP caused luteolysis in cows and heifers, as indicated by a decline (P les...

This study was conducted to examine the effects of vitamin D, K and Ca co-supplementation on carotid intima-media thickness (CIMT) and metabolic status in overweight diabetic patients with CHD. This randomised, double-blind, placebo-controlled trial was conducted among sixty-six diabetic patients with CHD. Participants were randomly allocated into two groups to take either 5µg vitamin D, 90 µg ...