نتایج جستجو برای: 077 and 013
تعداد نتایج: 16828186 فیلتر نتایج به سال:
BACKGROUND In addition to their role in growth, cellular differentiation and homeostasis Retinoid X Receptors (RXR) regulate multiple physiological and metabolic pathways in various organs that have beneficial glucose and lipid (cholesterol) lowering, insulin sensitizing and anti-obesity effects. Rexinoids, compounds that specifically binds and activate RXR, are therefore considered as potentia...
Receptors for sphingosine-1-phosphate (S1P) have been identified only recently. Their medicinal chemistry is therefore still in its infancy, and few selective agonists or antagonists are available. Furthermore, the selectivity of S1P receptor agonists or antagonists is not well established. JTE-013 and BML-241 (also known as CAY10444), used extensively as specific S1P(2) and S1P(3) receptors an...
Multivariate quadratic systems can be used to construct both secure and efficient public key schemes. In this article, we introduce the necessary mathematical tools to deal with multivariate quadratic systems, present an overview of important schemes known so far and outline how they fit into a taxonomy of only four basic schemes and some generic modifiers. Moreover, we suggest new construction...
DNA topoisomerases 1 and 2 are enzymes that maintain DNA topology and play important essential genome functions, including DNA replication and transcription. Aberrant topoisomerases cause genome instability and a wide range of diseases, cancer in particular. Both Topo 1 and 2 are the targets of valuable anticancer drugs, such as camptothecin. It has been previously shown that artemisinin, a ses...
Four strains of Bordetella bronchiseptica (CSU-P-1, 64-C-0406, 1120-A-83-013, and B205BT) with defined virulence for neonatal swine were examined, and an attempt was made to correlate the presence of certain in vitro phenotypic characteristics with the ability of a particular B. bronchiseptica strain to produce turbinate and lung lesions in piglets. All of the strains except CSU-P-1 colonized t...
Abstract Aim show our technique for abdominal wall graft retrieval minimizing warm ischemia time. Material and methods a video report of an (full-thickness) from female brain death donor. Results better perfusion with lower picnosis in the studied cells. Lower tissue damage both full-thickness isolated fascia grafts. Surgical technique: An “house-flap” incision is done as opposed to conventiona...
We present a full result for the 2+1 flavor QCD equation of state. All the systematics are controlled, the quark masses are set to their physical values, and the continuum extrapolation is carried out. This extends our previous studies [JHEP 0601:089 (2006); 1011:077 (2010)] to even finer lattices and now includes ensembles with Nt = 6, 8, 10, 12 up to Nt = 16. We use a Symanzik improved gauge ...
This case discusses the management of an 83-year-old female patient from Lebanon with Sjogren's Syndrome and Cicatricial Bullous Pemphigoid. The presented in January 2021 to internal medicine clinic for evaluation on off pruritic, burning blisters lower abdomen pubic area. She has hypothyroidism a 40 year long history difficulty exhaling through her nose. Family social unremarkable except using...
1) CGUL, IDL, University of Lisbon, Faculdade de Ciencias Ed. C8, Campo Grande, PT-1749-016 Lisbon, Portugal 2) Institute for Atmospheric and Climate Science, ETH, Universitaetsstr. 16, CH-8092 Zurich, Switzerland 3) Moscow State University, Research Computing Center, Faculty of Geography, GSP-1, Leninskie Gory, building 4, RU-119991 Moscow, Russia 4) European Centre for Medium-Range Weather Fo...
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