Anti– 2–glycoprotein I antibodies are known to have a heterogeneous reactivity against 2–glycoprotein I. We performed this study to characterize the epitope on 2–glycoprotein I to which pathologic anti– 2–glycoprotein I antibodies are directed. Plasma samples from 198 patients with various systemic autoimmune diseases were tested for the presence of lupus anticoagulant and anti– 2–glycoprotein ...

Based on the hypothesis that the viral load of cells infected with EHV-4 will likely change during the course of disease, TaqMan PCR was used to investigate and characterize the kinetics of EHV-4 viral DNA load (glycoprotein B gene) and transcriptional activity (glycoprotein B and latency-associated transcripts) in peripheral blood leukocytes (PBLs) and nasopharyngeal secretions (NSs) collected...

B ivalirudin and cangrelor are 2 intravenous drugs, 1 for anticoagulation and the other for antiplatelet therapy, with a rapid onset of action, thus in theory perfectly adapted to percutaneous coronary intervention (PCI) that requires simultaneous thrombin and platelet inhibition. These effects are especially needed for mechanical coronary reperfusion of acute patients such as those presenting ...

For detection of infectious laryngotracheitis virus (ILTV) antibody, glycoprotein B-, C-, and D-based enzyme-linked immunosorbent assays (B-, C-, and D-ELISAs, respectively) were developed. The B- and D-ELISAs showed enhanced detection of anti-ILTV antibodies in infected chickens compared to that of the commercial ELISA. Furthermore, the D-ELISA was efficient in detecting seroconversion with ve...

Background and Aims: Glycoprotein B (gB) is among the most important immunogenic proteins of HSV-1 that is now being used as recombinant vaccine to induce protectively against the virus. It is believed that gB is responsible for induction of neutralizing antibody and up to 90% of CTL (Cytotoxic T Cell) activity against HSV-1 in some haplotypes. Methods: In the present study the antibody titer ...

The lepidopteran-specific P1 delta-endotoxin of Bacillus thuringiensis var. kurstaki HD-1 was activated in vitro using insect gut proteases and found to be highly specific for the lepidopteran cell line Choristoneura fumiferana CF1 among a wide range of lepidopteran and dipteran cell lines tested. The toxicity of P1 against CF1 cells is inhibited by N-acetylgalactosamine (GalNAc), and the lecti...

Since November 2019, SARS-CoV-2 has been a matter of global concern due to its rapid spread, the millions deaths it caused, and repeated waves infections. One after another, many variants this novel virus have come into existence constant mutability, specifically in spike glycoprotein region. The tally for (VOCs), which already include Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1) Delta (B.1.617...