The acetylation modification process of histone has an essential role in the epigenetic regulation gene expression. This is controlled by balance between deacetylases (HDAC) and acetyltransferases (HAT). HDACs are thought to be vital for cell function. Particularly, higher HDAC expression frequent various cancers, resulting dysregulation several target genes involved proliferation, differentiat...

4-Methyl-5-pentylbenzene-1,3-diol (MPBD) (1) and dictyoquinone (DQ or 2-hydroxy-5-methyl-6-pentyl-1,4-benzoquinone) (2) are two polyketides involved in the cell development of Dictyostelium discoideum. We synthesized several MPBD DQ analogs tested their ability to recover aggregation delay stlA null strain. According findings, alkyl side chain both compounds facilitates activity. The parent n-p...

Coumarin and their derivatives have drawn much attention in the pharmacological and pharmaceutical fields due to their broad range and diverse biological activities. In the present work, starting from the 6-amino-7-hydroxy-4-methyl-2H-chromen-2-one, a series of 6-(substituted benzylamino)-7-hydroxy-4-methyl-2H-chromen-2-ones 1-11 was synthesized and assessed for their anti-inflammatory activity...

Tamarindus indica is one of the medicinal plants used in treatment various diseases traditionally.
 Aims: This study was conducted to identify phytochemical constituents T. leaf extracts. Methods: Using Fourier-transform infrared spectroscopy (FT-IR) and gas chromatography-mass spectrometry (GC-MS) identification bioactive compounds extracts indica.
 Results: The FT-IR spectrum confir...

A reaction of methyl (4R,5R)-4,5-epoxy-2(E)-hexenoate 1 with N-benzylmethylamine gave a diastereomerically pure methyl (4R,5R)-4,5-epoxy-(3S)-N-benzylmethylamino hexanoate 6 and methyl (4S,5R)-4-N-benzyl-methylamino-5-hydroxy-2(E)-hexenoate 7. The former was chemoenzymatically converted to (-)-osmundalactone 11, which is an aglycone of osmundalin. On the other hand, the directly conjugated addi...

The influence of the substituent at the C2 position on the hydrogen-bonding patterns is compared for a series of five related compounds, namely (±)-3-exo,6-exo-dibromo-5-endo-hydroxy-3-endo-nitrobicyclo[2.2.1]heptane-2-exo-carbonitrile, C(8)H(8)Br(2)N(2)O(3), (II), (±)-3-exo,6-exo-dibromo-6-endo-nitro-5-exo-phenylbicyclo[2.2.1]heptan-2-endo-ol, C(13)H(13)Br(2)NO(3), (III), (±)-methyl 3-exo,6-ex...