BACKGROUND It is unknown if discontinuation of targeted therapy (TT) and readministration in case of recurrence is feasible in patients with metastatic renal cell carcinoma (mRCC) in which complete response (CR) is achieved by TT alone or no evidence of disease (NED) with additional resection of residual metastases. PATIENTS AND METHODS Patients in whom TT was discontinued after CR to TT alon...

We prove that the number of Hamilton cycles in the random graph G(n, p) is n!p(1 + o(1)) a.a.s., provided that p ≥ ln n+ln ln n+ω(1) n . Furthermore, we prove the hitting-time version of this statement, showing that in the random graph process, the edge that creates a graph of minimum degree 2 creates ( ln n e )n (1+o(1)) Hamilton cycles a.a.s.

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In this paper we present COMET, a Gaussian process emulator of the galaxy power spectrum multipoles in redshift-space. The model predictions are based on one-loop perturbation theory and consider two alternative descriptions redshift-space distortions: one that performs full expansion real- to mapping, as recent effective field models, another preserves non-perturbative impact small-scale veloc...

In haploid and diploid S. cerevisiae the dimer yield ratio TT/CT is found to be 1.2/1 and 1.3/1, resp., at the UV (254 nm) unit dose 1 erg/mm2, the share of TT and CT in a UV (254 nm) lethal hit being 0.7 TT and 0.6 CT. A general formulation of the UV lethal hit is given and discussed. The TT+CT yields obtained for S. cerevisiae are compared to those reported for other organisms. It is found th...

Let Ln be the length of a longest increasing subsequence in a random permutation of {1, ..., n}. It is known that the expected value of Ln is asymptotically equal to 2 √ n as n gets large. This note derives upper bound on the probability that Ln − 2 √ n exceeds certain quantities. In particular, we prove that Ln − 2 √ n has order at most n1/6 with high probability. Our main result is an isoperi...

OBJECTIVES Lupus nephritis (LN) is frequently associated with a poor long-term prognosis. Renal biopsy is the diagnostic method of choice in this condition. Urine biomarkers have been mentioned in the diagnosis of LN. The study(,)s purpose was to evaluate the performance of urinary monocyte chemoattractant protein 1(UMCP-1) as a biomarker of renal involvement in systemic lupus erythematosus. ...

Let Ln,t be the set of all n-vertex connected graphs with clique number t (2 ≤ t ≤ n). For nvertex connected graphs with given clique number, lexicographic ordering by spectral moments (S-order) is discussed in this paper. The first ∑⌊(n−t−1)/3⌋ i=1 (n − t − 3i) + 1 graphs with 3 ≤ t ≤ n − 4, and the last few graphs, in the Sorder, among Ln,t are characterized. In addition, all graphs in Ln,n ∪...

In order to gauge the role that active galactic nuclei (AGN) play in evolution of galaxies via effect kinetic feedback nearby QSO$\,$2's ($z\sim0.3$), we observed eight such objects with bolometric luminosities $L_{bol} \sim 10^{46}\rm{erg\,s^{-1}}$ using Gemini GMOS-IFU's. The emission lines were fitted at least two Gaussian curves, broadest which attributed gas kinetically disturbed by an out...