We generalize the notion of ‘diagonal’ from the class of CSL algebras to masa bimodules. We prove that a reflexive masa bimodule decomposes as a sum of two bimodules, the diagonal and a module generalizing the w*-closure of the Jacobson radical of a CSL algebra. The latter module turns out to be reflexive, a result which is new even for CSL algebras. We show that the projection onto the direct ...

It is currently unclear whether tissue changes surrounding multifocal epithelial tumors are a cause or consequence of cancer. Here, we provide evidence that loss of mesenchymal Notch/CSL signaling causes tissue alterations, including stromal atrophy and inflammation, which precede and are potent triggers for epithelial tumors. Mice carrying a mesenchymal-specific deletion of CSL/RBP-Jκ, a key N...

The outcome of the Notch pathway on proliferation depends on cellular context, being growth promotion in some, including several cancers, and growth inhibition in others. Such disparate outcomes are evident in Drosophila wing discs, where Notch overactivation causes hyperplasia despite having localized inhibitory effects on proliferation. To understand the underlying mechanisms, we have used ge...

The radial scar (RS) or complex sclerosing lesion (CSL) of the breast represents a management dilemma on diagnosis at breast core needle biopsy because of the risk of associated malignancy identified only upon surgical excision. To determine our experience, we retrospectively reviewed core needle biopsies performed at the Darlene G. Cass Breast Imaging Center from 2006 to 2011, identifying 67 p...

The industrial washing of corn grain during its milling generates a residue known as “corn steep liquor (CSL)”. This is rich in amino acids, carbohydrates, vitamins, and mineral nutrients that can stimulate the vegetative growth when applied to plants. However, mode action this product not yet known. work involved foliar root application pepper plants, at dose 5 mL L−1, two CSL products (CSL-H ...

The relevance of this work lies in the fact that it is first time corn steep liquor (CSL) has been proposed as a unique source nutrients for producing biosurfactants controlled fermentation and Aneurinibacillus aneurinilyticus, isolated from CSL, evaluated extracellular cell-bound fermentation, using secondary raw materials nutrients. In present study, A. aneurinilyticus was inoculated into cul...

The effects of cholesterol on the dynamics of cholestane spin probe (CSL) in various phosphatidylcholine-cholesterol mixed model membranes are examined. The lateral diffusion, D of CSL in DMPC/POPC/cholesterol ternary mixtures, is measured utilizing an improved dynamic imaging electron spin resonance method. It shows a factor of two decrease at 10 mol % and 25 degrees C, whereas it shows only a...

Notch is a phylogenetically conserved transmembrane receptor that is required for many aspects of animal development. Upon ligand stimulation, a fragment of Notch is released proteolytically and enters the nucleus to form a complex with the DNA-binding protein CSL (CBF1/Suppressor of Hairless/Lag1) and activate transcription of Notch-CSL target genes. The physical structure of the Notch-CSL com...

Disclosure: David Parr has received honoraria for advising CSL Behring and Grifols (formerly Talecris), in addition to sponsorship from AstraZeneca and Boehringer Ingelheim. Emer Reeves and Niels Seersholm have no competing interests to disclose; however, both have received honoraria for this educational activity funded by CSL Behring. Kenneth R. Chapman has received compensation for consulting...