The possible involvement of the PI3K/AKT/BDNF/VGF signaling in rapid-acting antidepressant-like effects of antidepressants has been explored progressively by more studies. However, whether this signaling participates in the antidepressant-like effects of acetyl-l-carnitine (ALC) has not been examined. Herein, we assessed the antidepressant-like effects of ALC using the forced swimming test (FST...

Present study deals with the hepatoprotective activity of polyherbal formulation Hepatoplus (HP) as an oral supplement to the INH and RIF induced hepatitis in experimental rats. Rats treated with INH and RIF show abnormal liver function with significant increase in serum transaminases, bilirubin and clotting time (CT) and significant decrease in total protein and Albumin, which is brings to nea...

OBJECTIVE Achillea millefolium (A. millefolium) is known as an orexigenic herb in Iranian traditional medicine. In this study, the possible orexigenic effect of hydro-alcoholic extract of A. millefolium was investigated by measuring plasmaghrelin level. MATERIALS AND METHODS Thirty male Wistar rats were divided into five groups. Control group received water. Treatment groups received 50, 100 ...

Granisetron, a serotonin 5-HT(3) receptor antagonist, widely used as an antiemetic drug following chemotherapy, has been found to improve learning and memory. In this study, effects of granisetron on spatial recognition memory and fear memory and the involvement of nitric oxide (NO) have been determined in a Y-maze and passive avoidance test. Granisetron (3, 10mg/kg, intraperitoneally) was admi...

Aluminium (Al) is the third most widespread metal in the environment. It is known to be toxic for human and animals. We have studied the effect of simultaneous oral treatment of docosahexaenoic acid on aluminum induced changes in serum lipid profile and vitamins. A total of twenty four male albino rats were taken and divided in to four groups (N=6). First control group was treated with normal s...

OBJECTIVE To evaluate the effect of ginger extract on the expression of NFkappaB and TNF-alpha in liver cancer-induced rats. METHODS Male Wistar rats were randomly divided into 5 groups based on diet: i) control (given normal rat chow), ii) olive oil, iii) ginger extract (100mg/kg body weight), iv) choline-deficient diet + 0.1% ethionine to induce liver cancer and v) choline-deficient diet + ...

Natural Products offer an alternative to synthetic radioprotectors being less toxic. In this study 50% alcoholic extract of Mentha piperita (ALM) was tested for its radioprotective ability in terms of radiation sickness and survival of Swiss albino mice. This drug was well tolerated at highest dose of 1000mg/kg b.wt./day for three consecutive days. All doses of drug provided significant protect...

OPT 6 is an optimisation programme through which optimisation of various drugs like phenytoin can be done. It is based on Bayesian Statistical Theory and Maximum Likelihood Estimation. This study was aimed to determine the steady state concentration equivalence using the Optimisation programme OPT 6 to compare 300mg once daily phenytoin and 100mg tid phenytoin. Epileptic outpatients attending n...

Here we aimed to observe the dose dependent genotoxic potential of benzene which may trigger the leukomogenic activity in bone marrow of rat. We used Wistar rat as a model and benzene was administrated orally at the doses of 50mg/ml/ day and 100mg/ml / day for 90 days which exhibited with definite signs of genotoxicity which may initiate carcinogenesis. Cellular stress of bone marrow was evalua...

Hyperglycemia is a defining characteristic of diabetes and also occurs in pre-diabetic states. Normal blood glucose levels are between 70 and 100mg/dL. Blood levels of greater than 100mg/dL glucose are recognized as being hyperglycemic. Glucose levels of greater than 125mg/dLare recognized as being diabetic. Impaired glucosetolerance (fasting glucose > 110mg/dL) was investigated in a large coho...