CC-1065, the duocarmycins and yatakemycin are members of a family of ultrapotent antitumour antibiotics that have been the subject of extensive investigations due to their mode of action and potential in the design of new anticancer therapeutics. The natural products and their analogues exert their effects through a sequence selective alkylation of duplex DNA in the minor groove at the N3 of ad...

Intervention in Obesity & Diabetes The Emphasis on Remission of Type 2 through Diet Elisabeth Govers RD* Dutch Knowledge Centre Obesity, Netherlands *Corresponding author:Elisabeth RD, C van Alkemadestraat 16, 1065 AC Amsterdam, Submission:February 01, 2023;Published: February 09, 2023 DOI: 10.31031/IOD.2023.06.000630 ISSN 2578-0263Volume6 Issue1

P. Pérez-Fernández, A. Relaño,* J. M. Arias, J. Dukelsky, and J. E. García-Ramos Departamento de Física Atómica, Molecular y Nuclear, Facultad de Física, Universidad de Sevilla, Apartado 1065, 41080 Sevilla, Spain Instituto de Estructura de la Materia, CSIC, Serrano 123, E-28006 Madrid, Spain Departamento de Física Aplicada, Universidad de Huelva, 21071 Huelva, Spain Received 3 July 2009; publi...

A. Relaño,* J. M. Arias, J. Dukelsky, J. E. García-Ramos, and P. Pérez-Fernández Instituto de Estructura de la Materia, CSIC, Serrano 123, E-28006 Madrid, Spain Departamento de Física Atómica, Molecular y Nuclear, Facultad de Física, Universidad de Sevilla, Apartado 1065, 41080 Sevilla, Spain Departamento de Física Aplicada, Universidad de Huelva, 21071 Huelva, Spain Received 18 June 2008; publ...

We explain how the Elliptic Curve Primality Proving algorithm can be implemented in a distributed way. Applications are given to the certiication of large primes (more than 500 digits). As a result, we describe the successful attempt at proving the primality of the 1065-digit (2 3539 +1)=3, the rst ordinary Titanic prime.