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Background: Immune-associated adverse pregnancy is the outcomes induced by autoimmune factors or diseases, including infertility, recurrent spontaneous abortion, failed assisted reproduction, fetal growing restriction. It helpful to explore mechanism and improve management analyzing clinical characteristics of patients with immune-associated pregnancy. Objectives: To find risk Methods: The invo...
Design and Methods. Twenty-four patients with advanced hematologic malignancies were included. PBSC were collected in matched (N=16) or one-mismatch (N=8) related donors and CD34-selected. On day 60, donors donated lymphocytes that were CD8-depleted and separated into 3 aliquots containing 2×106, 1×107 and 5×107 CD3+ cells/kg (patients 1-13) or into 2 aliquots containing 1×107 and 5×107 CD3+ ce...
CDK5R1 encodes p35, a specific activator of the serine/threonine kinase CDK5, which plays crucial roles in CNS development and maintenance. CDK5 activity strongly depends on p35 levels and p35/CDK5 misregulation is deleterious for correct CNS function, suggesting that a tightly controlled regulation of CDK5R1 expression is needed for proper CDK5 activity. Accordingly, CDK5R1 expression was demo...
Corynebacterium renale type I (strain 115), 1.7 x 107 to 4.5 x 107 organisms, introduced intravenously into mice disappeared from the blood less than 24 h after inoculation and did not produce pyelonephritis. The same strain, 1 x 107 to 5 x 107 organisms, inoculated into the urinary bladder of mice was not recovered from the blood in any of the mice, but caused pyelonephritis accompanied by ure...
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