Surface molecules play important roles in a wide range of cellular functions, yet little has been reported regarding the expression of such markers by neural stem cells. Here, multipotent human neural progenitor cells (hNPCs) were expanded as a monolayer in the presence of fibroblast/epidermal growth factor, harvested, labeled with monoclonal antibodies, and analyzed by flow cytometry. Positive...

The main purpose of the present paper was: (1) to study the phase synchronization pattern in the g-band while performing the classical Shepard±Metzler task of mental rotation; (2) to investigate the role of musical training; and (3) to study hemispheric differences in the degree of synchronization during mental rotation. Multivariate electroencephalograph signals from 20 male subjects (ten musi...

Rats prenatally exposed to the neurotoxins methylazoxymethanol (MAM) or 5-Bromo-2 0-deoxyuridine (BrdU) are used as animal models of brain maldevelopment. We administered in rats MAM (20 mg/kg), or BrdU (100 mg/kg) or both at gestational day 11. Locomotion was not affected by any prenatal treatment whereas learning was delayed in the Morris maze in MAM animals. BrdU induced decreased NGF and BD...

Drebrin has been known to act on actin filaments at dendritic spines to cause morphological change, and might be related to the plasticity of synaptic transmission. In the present study, changes of drebrin were examined immunohistochemically in the spinal motoneurons of rats following unilateral sciatic nerve transection. Drebrin-immunoreactivity (ir) in the motoneurons was significantly increa...

Neural recordings from the primary motor cortex of monkeys performing movements at an angle to a cue stimulus have yielded two main results: (A) the population vector rotates from the direction of the cue to the direction of movement, and (B) cells with intermediate preferred directions are recruited during the middle of this rotation. These results have been interpreted as the neural correlate...

Cerebellar granule neurons can be maintained in culture in a medium containing high serum and depolarising levels of KCl. When serum is removed and the KCl levels lowered from 25 to 5 mM, the cells undergo apoptosis. Apoptosis can be prevented by inhibitors of transcription or translation, suggesting a need for macromolecular synthesis in the apoptotic process. Using quantitative reverse transc...

Trajectories of the hands and whole-body center of mass were studied during whole-body lifting tasks. The movements of different parts of the body were monitored with the ELITE system. Subjects were instructed to lift to shoulder height an object placed at one of two distances (5±45 cm) before them on the ̄oor. The lifts were performed both with and without kinematics constraints (i.e. to produ...

The neural correlates of the selection of grammatical gender during overt picture naming were investigated by eventrelated functional magnetic resonance imaging in the left hemisphere. Relative to simply naming a picture, the production of the definite determiner of the picture name (requiring gender selection) resulted exclusively in pronounced activation of a single region in the superior por...

Simultaneous lightness contrast is a classical visual illusion, which has been the focus of research for several generations of visual scientists. Still, there is no agreement on its mechanisms. There are two main competing accounts. The first is descended from ideas of Ewald Hering [Hering, E., Outline of a Theory of the Light Sense, (1874), translated from the German by L. Hurvich and D. Jame...

Regional activation of the brain was studied in humans using functional magnetic resonance imaging during whole body cooling that produced thermal comfort/discomfort. Eight normal male subjects lay in a sleeping bag through which air was blown, exposing subjects to cold air (88C) for 22 min. Each subject scored their degree of thermal comfort and discomfort every min. As the subjects reported m...