Morphology and changes in gene expression of vascular endothelium are mainly due to shear stress and inflammation. Cell phenotype modulation has been clearly demonstrated to be controlled by small noncoding micro-RNAs (miRNAs). This study focused on the effect of laminar shear stress (LSS) on human endothelial cells (HUVECs), with an emphasis on the role of miRNA-126 (miR-126). Exposure of HUVE...

The SUSY $SO(10)$ GUT is in severe tension with the experimental bounds on proton partial lifetimes because decay mediated by colored Higgsinos (dimension-five decay) too rapid. In this paper, we pursue possibility that a texture of Yukawa coupling matrices renormalizable model suppresses dimension-five decay. We focus general which contains ${\bf 10}+{\bf 126}+{\bf \overline{126}}+{\bf 120}$ r...

College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China; [email protected] (Y.Z.); [email protected] (Z.L.); [email protected] (X.W.); [email protected] (D.P.); [email protected] (Y.L.); [email protected] (X.H.); [email protected] (X.M.); [email protected] (L.H.); [email protected] (Y.Y.) * Correspondence: [email protected]...

Aim: MicroRNA-126 (miR-126) exerts beneficial effects on vascular integrity, angiogenesis, and atherosclerotic plaque stability. The purpose of this investigation was to analyze the dose-response relationship of high-intensity interval training (HIIT) on miR-126-3p and -5p levels. Methods: Sixty-one moderately trained individuals (females = 31 [50.8%]; 22.0 ± 1.84 years) were consecutively recr...

OBJECTIVE MicroRNAs are involved in many critical functions, including angiogenesis. Ultrasound-targeted microbubble destruction (UTMD) is a noninvasive technique for targeted vascular transfection of plasmid DNA and may be well suited for proangiogenic microRNA delivery. We aimed to investigate UTMD of miR-126-3p for therapeutic angiogenesis in chronic ischemia. APPROACH AND RESULTS The angi...

chao qin ([email protected]) shangqian wang ([email protected]) pu li ([email protected]) qiang cao ([email protected]) pengfei shao ([email protected]) pengchao li ([email protected]) zhijian han ([email protected]) jun tao ([email protected]) xiaoxin meng ([email protected]) xiaobing ju ([email protected]) rijin song ([email protected]) jie li ([email protected]) wei zhang (zhang...

Adhesion molecules expressed by activated endothelial cells play a key role in regulating leukocyte trafficking to sites of inflammation. Resting endothelial cells normally do not express adhesion molecules, but cytokines activate endothelial cells to express adhesion molecules such as vascular cell adhesion molecule 1 (VCAM-1), which mediate leukocyte adherence to endothelial cells. We now sho...

The endothelial cell-specific microRNA (miRNA), miR-126, is considered a master regulator of physiological angiogenesis. Transplanted mesenchymal stem cells (MSCs) release soluble factors contributing to neoangiogenesis and cardiac repair. Therefore, we hypothesized that the over-expression of miR-126 may prolong MSC survival and enhance the cell secretome, thereby improving post-infarction ang...

Prion disorder-related neurodegenerative diseases are characterized by the accumulation of prion protein (PrP) scrapie isoform (PrPsc) within the central nervous system. PrPsc induces neuronal cell death by increasing intracellular generation of reactive oxygen species (ROS). Lactoferrin (LF) is an 80 kDa protein, which has antioxidant abilities due to the scavenging of ROS. The effects of LF t...