For efficient ligand binding, integrins must be activated. Specifically, a conformational change has been proposed in a ligand binding domain present within some integrins, the inserted (I) domain [Lee, J., Bankston, L., Arnaout, M. & Liddington, R. C. (1995) Structure (London) 3, 1333-1340]. This proposal remains controversial, however, despite extensive crystal structure studies on the I doma...

The NiO and Fe2O3 powders were mixed by the high-energy ball-milling, followed a sintering of mixture at 1340°C for 0.5 h. XRD, SEM, DSC, size measurements preformed to study microstructure evolution in ball-milled sintered ones, as well. It showed that ball-milling processes resulted severe lattice distortion powder Fe2O3, but only slight NiO. Meanwhile, solid solution iron atoms into was also...

We aim to review available literature related to the telemonitoring of maternal health care for a comprehensive understanding of the roles of Medical Cyber-Physical-Systems (MCPS) as cutting edge technology in maternal risk factor management, and for understanding the possible research gap in the domain. In this regard, we search literature through google scholar and PubMed databases for publis...

BACKGROUND The role of renin-angiotensin inhibition in older patients with diastolic heart failure and chronic kidney disease remains unclear. METHODS Of the 1340 patients (age ≥65 years) with diastolic heart failure (ejection fraction ≥45%) and chronic kidney disease (estimated glomerular filtration rate <60 mL/min/1.73 m(2)), 717 received angiotensin-converting enzyme inhibitors or angioten...

BACKGROUND Safety concerns for fluoroquinolones exist from animal studies demonstrating cartilage injury in weight-bearing joints, dependent on dose and duration of therapy. For children treated with levofloxacin or comparator in randomized, prospective, comparative studies for acute otitis media and community-acquired pneumonia, this 5-year follow-up safety study was designed to assess the pre...

The large nucleoporin Nup358/RanBP2 forms eight filaments that project from the nuclear pore into the cytoplasm where they function as docking platforms for nucleocytoplasmic transport receptors. RNAi screens have implicated Nup358 in the HIV-1 life cycle. The 164 C-terminal amino acids of this 3,224 amino acid protein are a cyclophilin homology domain (Nup358Cyp), which has potential to bind t...

Normal aging is associated with progressive changes in cellular function. Keratinocytes experience continual cycles of division and renewal as well constant exposure to external stimuli, while the balance between unperturbed cumulative effects environmental exposures are not completely defined. We isolated keratinocytes from 12 mice aged 3-86 weeks found 876 differentially methylated regions by...

Diffuse reflectance FTIR measurements with two-dimensional correlation spectroscopy (2D-COS) are used for accurate band identification of chernozem comprising soil organic matter (SOM), including humic substances and mineral silicate matrix. Samples different land use (native steppe, shelterbelt, bare fallow, arable land) a long-term field experiment were compared. Homospectral 2D-COS maps size...