Diterpene glucoside fusicoccin A (FC-A) is a phytotoxic fungal metabolite that stabilizes the interactions between 14-3-3 protein and phosphorylated ligand protein. 14-3-3-mediated binding central to regulation of serine/threonine kinase signaling pathway in all eukaryotic cells essential for controlling numerous biological processes. Thus, fusicoccins could serve as robust platform developing ...

Objective(s): Resistance to medications is one of the main complications in chemotherapy of cancer. It has been shown that some multidrug resistant cancer cells indicate more sensitivity against cytotoxic effects of TNF-α compared to their parental cells. Our previous findings indicated vulnerability of the mitoxantrone-resistant breast cancer cells MCF-7/MX to cell de...