he protein that does everything, 14–3-3, has now been shown to direct traffic. Ita O'Kelly, Steve Goldstein, and colleagues (Yale University, New Haven, CT) find that 14–3-3 can displace ␤-COP from various proteins, thus freeing them from retention in the ER and leading to surface expression. Goldstein set out to find proteins interacting with the COOH terminus of a K ϩ leak channel, KCNK3, and...

We report on a 47-year-old woman with autopsy proven Creutzfeldt-Jakob disease (CJD), who had a positive initial 14-3-3 test but a subsequent negative test under pharmacologic suppression of the periodic epileptiform discharges on EEG. Multiple factors associated with a subsequent 14-3-3 test becoming negative are known. However none of these circumstances were applicable to our patient. This c...

Louis-Lucien Bonaparte printzeak, euskara sailkatzeko bere ahaleginean, nafar Pirinioko talaiatik so eginez nonbait, Iruñez haraindiko multzo handi bati aldaera gisako kategoria iritzi eta subdialecto ultra-pamplonés deitura eman zion, honen barruan Gulibarko hau, Oltzako Zizurko aldaerak kokatuz, guztiak ere hegoaldeko goi-nafarrera deitu zuen euskalkiaren barruan. Saio azpitituluan dakusagune...

The once obscure members of the 14-3-3 protein family play significant roles in the determination of cell fate. By inhibiting the pro-apoptotic BAD (Bcl-2-antagonist of cell death) and the transcription factor FKHRL-1, 14-3-3 displays important anti-apoptotic characteristics. To date, five points of interaction of 14-3-3 with the apoptotic machinery have been identified. How these interactions ...