Air pollution has been classified as a group 1 carcinogen in humans, but the underlying tumourigenic mechanisms remain unclear. In Xuanwei city of Yunnan Province, the lung cancer incidence is among the highest in China, owing to severe air pollution generated by the combustion of smoky coal, providing a unique opportunity to dissect lung carcinogenesis. To identify abnormal miRNAs critical for...

The number of individual RSD applications received by UNHCR offices worldwide nearly doubled from 1997 to 2001, while UNHCR's RSD operations have been criticized for failing to implement basic standards of procedural fairness. Yet, although there is some literature critiquing how UNHCR determines refugee status, there is little literature examining whether UNHCR should do so, and if it should, ...

We continue to formalize the concept of the Generalized Full Addition and Subtraction circuits (GFAs), define the structures of calculation units for the Redundant Signed Digit (RSD) operations, then prove its stability of the calculations. Generally, one-bit binary full adder assumes positive weights to all of its three binary inputs and two outputs. We define the circuit structure of two-type...

MicroRNAs are endogenous noncoding RNAs that play important roles in a wide variety of biologic processes such as apoptosis, development, aging, and tumorigenesis. The B-cell lymphoma 6 (BCL6) transcriptional repressor has emerged as a critical therapeutic target in diffuse large B-cell lymphomas (DLBCL), but the mechanisms regulating BCL6 are still unclear. In the current study, we screened th...

Background: MicroRNA (miR) dysregulation is found in Alzheimer's disease (AD). A disintegrin and metalloprotease 10 (ADAM10) prevents generation of amyloid β (Aβ) and decrease AD pathology. Results: miR-144 suppresses ADAM10 expression and is up-regulated by activator protein-1. Conclusion: miR-144 is negative regulator of ADAM10 and may be involved in AD pathogenesis. Significance: The first w...

A free range system of poultry production is an important economical investment to most the poor farmers as a source income and protein, however it faces several challenges including parasitic diseases such ectoparasite infestation. cross-sectional study was undertaken determine prevalence ectoparasites, well assess possible predisposing risk factors infesting free-ranging local chickens in urb...