OBJECTIVES Raltegravir is the first approved inhibitor of HIV-1 integrase (IN). In most patients, raltegravir failure is associated with mutations in the IN gene, through two different genetic pathways: 155 (N155H) or 148 (Q148K/R/H). The objective of this study was to characterize the dynamics of HIV-1 quasispecies variant populations in patients who failed to respond to raltegravir treatment....

Histone acetyltransferase mortality factor 4-like 1 (MORF4L1) is a relatively new histone acetyltransferase component that exists as a homodimer to exert its epigenetic function. The mechanism of MORF4L1 self-assembly is unknown. Here we report that Lys-148 deacetylation is indispensable for facilitating MORF4L1 self-assembly into a homodimeric unit. Among a stretch of ∼10 amino acids in the NH...

Abstract Aim Posterior malleolus (PM) fractures are a common and significant injury. Historically, only constituting >30% of the joint surface were managed operatively, however more recent research suggests that type fracture injury mechanism carry importance. This study compared patient outcome scores with most classification systems, percentage tibial plafond involved (PTP) fixation me...

Pneumatization of the petrous apex was investigated in 226 subjects without middle ear disease by means of target imaging CT. The degree of pneumatization of all subjects was 32.7% (148/452 ears), but no difference in degree was revealed with distinction of bilateral ears or between sexes. In 148 ears with pneumatization of the petrous apex, a higher degree of pneumatization was found in larger...

BACKGROUND Normal saline (NS) is the most commonly used crystalloid solution worldwide but contains an excess of chloride and may cause metabolic acidosis and hyperchloraemia. Such abnormalities may be attenuated by the use of a balanced solution such as Plasma-Lyte 148 (PL-148). OBJECTIVE To assess the feasibility, safety and biochemical and physiological effects of resuscitation with NS ver...

BACKGROUND The incidence of serotonin syndrome is increasing due to the widening use of serotonergic drugs. Identification of serotonin syndrome is challenging as the manifestations are diverse. Misdiagnosis can lead to delay in care and inappropriate treatment. OBJECTIVES The objectives of this study were to determine if staff of community pharmacies in Australia could identify the symptoms ...