FKBP52 is a tetratricopeptide repeat (TPR) protein with peptidyl-prolyl isomerase activity and is found in steroid receptor complexes, including glucocorticoid receptor (GR). It is generally accepted that FKBP52 has a stimulatory effect on GR transcriptional activity. However, the mechanism by which FKBP52 controls GR is not yet clear, with reports showing effects on GR hormone-binding affinity...

The structure of purified preparations of activated (DNA-binding) glucocorticoid receptor (GR) was analyzed in the presence or absence of DNA. A 35-base pair DNA fragment harboring a strong GR-binding site from the mouse mammary tumor virus promoter (-189/-166) was used for stoichiometric analysis of the GR . DNA complex. Glycerol gradient centrifugation was utilized in order to separate the 6 ...

Abnormal glucocorticoid and neurotrophin signaling has been implicated in numerous psychiatric disorders. However, the impact of neurotrophic signaling on glucocorticoid receptor (GR)-dependent gene expression is not understood. We therefore examined the impact of brain-derived neurotrophic factor (BDNF) signaling on GR transcriptional regulatory function by gene expression profiling in primary...

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We consider the impact of two recent π − p → ηn measurements on the ηN scattering length and ηN branching fractions for the N (1535) and N (1520) resonances within a coupled-channel analysis of πN elastic scattering and ηN production data. The sensitivity of these results to model input is also explored.

We experimentally study a new regime for supercontinuum (SC) generation in the nanosecond pulsed regime using a microstructured optical fiber with two zero-dispersion wavelengths (ZDWs). Pumping at 1535 nm around the second ZDW yields a nearly flat SC over 1350–1700 nm. The interplay between the effects of modulation instability and stimulated Raman scattering are described through simple phase...

Respiratory syncytial virus (RSV)-induced bronchiolitis in infants, although inflammatory in nature, is not responsive to glucocorticoids. We have recently shown that RSV-infected lung epithelial cells have impaired glucocorticoid receptor (GR)-mediated transactivation. In this study, we show that the N-terminal region of GR is required for RSV repression of GR transactivation and that RSV infe...