Elevation of intracellular cAMP and activation of protein kinase A (PKA) lead to activation of large conductance voltage- and Ca(2+)-activated K(+) (BK) channels, thus attenuation of detrusor smooth muscle (DSM) contractility. In this study, we investigated the mechanism by which pharmacological inhibition of cAMP-specific phosphodiesterase 4 (PDE4) with rolipram or Ro-20-1724 (C(15)H(22)N(2)O(...

BACKGROUND Alterations in myocardial function and systemic vascular tone are well documented in congestive heart failure (CHF), but little information is available on the effects of CHF on pulmonary vessels. We examined the mechanisms of tone regulation of canine pulmonary arteries during pacing-induced CHF. METHODS AND RESULTS Rings 3-4 mm wide from lobar pulmonary arteries were prepared fro...

The X-ray burster 1E1724-3045 located in the globular cluster Terzan 2 is known as one of the persistent (though variable) hard X-ray sources as shown by the SIGMA observations of the Galactic Center region. 1E1724-3045 was observed with the PCA and HEXTE experiments onboard the Rossi X-ray Timing Explorer (RXTE) on November 1996 for about 100 ksec. The broad band spectral capability and sensit...

BACKGROUND Attribution of early cancer symptoms to a non-serious cause may lead to longer diagnostic intervals. We investigated attributions of potential cancer 'alarm' and non-alarm symptoms experienced in everyday life in a community sample of adults, without mention of a cancer context. METHODS A questionnaire was mailed to 4858 adults (≥50 years old, no cancer diagnosis) through primary c...

Inoculation of golden Syrian hamsters with Venezuelan encephalitis (VE) virus results in a sustained diminution in glucose-stimulated insulin release that is correctable by cyclic (c) AMP analogs and phosphodiesterase inhibitors. This suggested the importance of directly measuring cAMP content in VE-infected and control islets in response to insulin secretagogues. The basal cAMP content of VE-i...

Abstract This article embarks on a tour of Brexit Britain in the company eighteenth-century writer Daniel Defoe. The closer text is his A Tour Through Whole Island Great , published between 1724 and 1726. Defoe wrote considerable part, as gentleman’s guide to newly ‘United’ Kingdom Britain. It seems apt revisit Defoe’s given stresses which presently test integrity this same union three centurie...