AMA Wołek M, Matusiak K, Machoczek P, Partyka Ł, Zasada W. Corrected QT interval in electrocardiogram recordings patients treated with calcium channel blockers. Advances Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2023;19(2):171-177. doi:10.5114/aic.2023.129216. APA Wołek, M., Matusiak, K., Machoczek, P., Partyka, Ł., & Zasada, (2023). Interwencyjnej, 19(2), 171-177. https:/...

BACKGROUND The aim of the study was to explore Fc mutations of a humanised anti-Lewis-Y antibody (IgG1) hu3S193 as a strategy to improve therapeutic ratios for therapeutic payload delivery. METHODS Four hu3S193 variants (I253A, H310A, H435A and I253A/H310A) were generated via site-directed mutagenesis and radiolabelled with diagnostic isotopes iodine-125 or indium-111. Biodistribution studies...

A single tool for early detection, accurate staging, and personalized treatment of prostate cancer (PCa) would be a major breakthrough in the field of PCa. Gastrin-releasing peptide receptor (GRPR) targeting peptides are promising probes for a theranostic approach for PCa overexpressing GRPR. However, the successful application of small peptides in a theranostic approach is often hampered by th...

The Escherichia coli lactose carrier is an energy-transducing H+/galactoside cotransport protein which strictly couples sugar and proton transport in 1:1 stoichiometry. Here we describe five lactose carrier mutants which catalyze "uncoupled" sugar-independent H+ transport. Symptoms similar to uncoupling by a proton ionophore have been observed in cells expressing these mutant carriers. The muta...

Amaç: Son yıllarda, hedefe yönelik radyonüklid tedavisindeki ilerlemeler sayesinde hastalıkların erken teşhis ve tedavisinde önemli gelişmeler kaydedilmiştir. Tanı tedavi yöntemlerini birleştiren “teranostik” kavramının doğmasıyla Lutesyum-177 (Lu-177), tedavide bir yer edinmiş bu alanda öncü bileşik haline gelmiştir. Bu derlemede, radyofarmasötikler, tedavi, teranostikler Lu-177 ile ilgili tem...

156 Jakaša, T., Osmanagić Bedenik, N., Iliopoulos, F., Određivanje učinkovitosti sustava..., Energija, god. 57(2008), br. 2., str. 156-177 Jakaša, T., Osmanagić Bedenik, N., Iliopoulos, F., Determination of the Effectiveness of Risk..., Energija, vol. 57(2008), No. 2, pp. 156-177 SUSTAVI UPRAVLJANJA RIZICIMA U PODUZEĆIMA ELEKTROPRIVREDE DETERMINATION OF THE EFFECTIVENESS OF RISK MANAGEMENT SYST...

This research studies the impact of information technology enabled coordination on product modularization in the automotive industry. A structural equation model is tested based on 177 responses to questionnaires from 177 Korean first tier automotive suppliers. The results provide support for the hypothesis that high quality of exchanged information enables better supply chain coordination, whi...

Acidic substituents for Ala-177 (helix 6) or Tyr-236 (helix 7) in LacY cause effects on sugar recognition and cosubstrate coupling that are stereotypical of neutral substituents. Thus, helices 6 and 7 are probably oriented to produce little side-chain contact with the low dielectric lipid bilayer at positions 177 and 236.