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More than 60 human immunodeficiency virus protease inhibitors were examined for the structure-activity relationship between metabolic stability, CYP3A4 inhibitory potency, and substrate-induced binding spectra with a ferric form of P450 in human liver microsomes. A positive relationship was found between CYP3A4 inhibitory potency and metabolic stability; namely, compounds that were more potent ...

Objective. Scholars continue to debate whether morally charged political issues constitute a distinct type of policy question or produce essentially the same political dynamic as public controversies lacking an overt moral dimension. The debate will not be resolved until scholars test the determinants of putative morality policies with predictors drawn both from morality politics theory and fro...

Since XML becomes a crucial format for representing information, it is necessary to establish techniques for managing XML documents. A possible solution can be found in storing XML data in (object-)relational databases. For this purpose most of the existing techniques often exploit an XML schema of the stored XML data, usually expressed in DTD. But the more complex today’s applications are, the...