background: detection of hepatitis c virus specific antibodies is the initial step in chronic hcv diagnosis.  hcv ns4b is among the most immunogenic hcv antigens and has been widely used in commercial enzyme immunoassays (eia). additionally, ns4b, a key protein in the virus replication, can be an alternative target for antiviral therapy.objectives: development of a new method for high-level exp...

Serine/arginine-rich (SR) proteins are associated with either the regulation or the execution of both constitutive splicing and the selection of alternative splice sites in animals and plants. We demonstrated the molecular characterization of a homolog of SR protein, atSR45a, in Arabidopsis plants. Six types of mRNA variants (atSR45a-1a-e and atSR45a-2) were generated by the alternative selecti...

The transcription factor HIF-1a is essential for cells to rapidly adapt to low oxygen levels (hypoxia). HIF-1a is frequently deregulated in cancer and correlates with poor patient prognosis. Here, we demonstrate that the deubiquitinase Cezanne regulates HIF-1a homeostasis. Loss of Cezanne decreases HIF-1a target gene expression due to a reduction in HIF-1a protein levels. Surprisingly, although...

One of the most fundamental molecular processes in response to hypoxia is activation and stabilization a transcriptional factor called induced 1a (HIF-1a), which responsible for regulation many downstream effector genes. Multiple key biological pathways such as proliferation, energy metabolism, invasion, metastasis are governed by these This article discusses role hypoxia-inducible (HIF-1a) met...

In the present paper, we describe the design, execution, and the results of an outdoor experimental campaign involving the Engineering Model of the first of the two Argentinean L-band Synthetic Aperture Radars (SARs) of the Satélite Argentino de Observación con Microondas (SAOCOM) mission, SAOCOM-1A. The experiment’s main objectives were to test the end-to-end SAR operation and to assess the in...

Hypoxia-inducible factor-1A (HIF-1A) is overexpressed in many human tumors and their metastases, and is closely associated with a more aggressive tumor phenotype. In this study, we investigated the effect of resveratrol, a natural product commonly found in grapes and various other fruits, on hypoxia-induced HIF-1A protein accumulation and vascular endothelial growth factor (VEGF) expression in ...

The transcription factor HIF-1a is essential for cells to rapidly adapt to low oxygen levels (hypoxia). HIF-1a is frequently deregulated in cancer and correlates with poor patient prognosis. Here, we demonstrate that the deubiquitinase Cezanne regulates HIF-1a homeostasis. Loss of Cezanne decreases HIF-1a target gene expression due to a reduction in HIF-1a protein levels. Surprisingly, although...