Background Fingolimod is a sphingosine-1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis (RRMS). Despite an established effect on heart rate, the effect of fingolimod on cardiac repolarization is not completely known. Methods Twenty-seven patients with RRMS underwent 24-hr ambulatory ECG before fingolimod (baseline), at the day of fingolimod initiation...

The Ca(v)1.3 (alpha(1D)) variant of L-type Ca(2+) channels plays a vital role in the function of neuroendocrine and cardiovascular systems. In this article, we report on the molecular and functional basis of alpha(1D) Ca(2+) channel modulation by protein kinase C (PKC). Specifically, we show that the serine 81 (S81) phosphorylation site at the NH(2)-terminal region plays a critical role in alph...

General SFM methods give poor results for images captured by constrained motions such as planar motion. In this paper, we propose new SFM algorithms for images captured under a common but constrained planar motion: the image plane is perpendicular to the motion plane. We show that a 2D image captured under such constrained planar motion can be decoupled into two 1D images: one 1D projective and...

Helical 1D electronic systems are a promising route towards realizing circuits of topological quantum states that exhibit non-Abelian statistics. Here, we demonstrate a versatile platform to realize 1D systems made by combining quantum Hall (QH) edge states of opposite chiralities in a graphene electron-hole bilayer at moderate magnetic fields. Using this approach, we engineer helical 1D edge c...

This paper is on efficient implementation techniques of Elliptic Curve Cryptography. In particular, we improve timings for Jacobiquartic (3M+4S) and Hessian (7M+1S or 3M+6S) doubling operations. We provide a faster mixed-addition (7M+3S+1d) on modified Jacobiquartic coordinates. We introduce tripling formulae for Jacobi-quartic (4M+11S+2d), Jacobi-intersection (4M+10S+5d or 7M+7S+3d), Edwards (...

Plant growth and development are ensured through networks of complex regulatory schemes. Genetic approaches have been invaluable in dissecting these regulatory pathways. This study reports the isolation of a semi-dominant dwarf mutant designated abnormal shoot1-1 dominant (abs1-1D) through an Arabidopsis T-DNA activation tagging mutant screen. It was shown that the overexpression of a novel BAH...

A long narrow gate across a fractional quantum Hall fluid at filling n51/m with odd integer m , creates a one-dimensional ~1D! system that is isomorphic to a disordered 1D electron gas with attractive interactions. By varying the gate potential along such a line junction, it should be possible to tune through the 1D localization transition, predicted for an attractively interacting electron gas...

A problem of interacting charge carriers confined in quasi-one-dimensional ~1D! semiconductor nanostructures has been studied. We have derived an analytical 1D formula for the effective interaction potential between the confined charge carriers. We have applied both the 1D model with the effective potential and the full three-dimensional ~3D! approach to an electron pair confined in a single an...

Recently, we proposed a new multiplierless 1D Int-DCT modified from our existing Int-DCT by approximating floating multiplications to bit-shift and addition operations. The multiplierless 1D Int-DCT can be well operated both lossless coding and lossy coding. However, our multiplierless 1D Int-DCT is not focused on how to assign word-length for floating-multiplier approximation as short as possi...

One dimensional (1D) silicon nanostructures have attracted significant interest as an anode material for lithium ion batteries (LIBs) as its 1D geometry accommodates the large volume change of the Si during cycling and enables facile electron transport during all stages of operation. Furthermore, the high aspect ratio of 1D Si nanostructures enables us to investigate atomic-scale mechanisms of ...