With our efforts to develop potent antimicrobial agents, a series of anthracene and 1,8-napthalimide aminothiazole analogues were synthesized characterized by using fundamental spectral analysis. All the hybrids screened for their anti-microbial activities against bacterial strains E. coli, B. subtillis, S. aureus, fungal A. niger C. albicans. Among compounds investigated, 4c, 4d, 6c exhibited ...

A series of Ugi reactions has been successfully performed using ammonia as the amine component, employing 2,2,2-trifluoroethanol as a non-nucleophilic solvent in order to suppress known side reactions. Utilizing concentrated aqueous ammonia as a convenient source, this approach offered a simple, one-step assembly of Ugi adducts suitable for elaboration into a variety of 5-aminoazole compounds t...


 1,3-Thiazole is one of the most attractive cores in heterocycles chemistry and drug discovery. Its widespread use diverse medicinal substances makes thiazole a versatile scaffold, which leads to novel generation efficient pharmaceuticals. This study was intended synthesize series N,N-disubstituted aminothiazole derivatives having various fragments at 4th 5th positions ring. The formation...