Background: Aflatoxin B1 (AFB1) is a mutagenic and carcinogenic compound mainly produced by the Aspergillus parasiticus, A. flavus, A. nomius, A. tamari, and A. pseudotamarii. AFB1 biodegradation is the most important strategy for reducing AFB1 in plant tissues. Bacteria can deactivate and biodegrade AFB1 for effective detoxification of contaminated products. The present study investigated the ...

Aflatoxin B1 (AFB1) is a secondary metabolite produced by Aspergillus flavus and A. parasiticus, known carcinogen in humans animals. High voltage atmospheric cold plasma (HVACP) technology has already shown promise to decontaminate AFB1 food feed. This study aimed investigate the cytotoxicity of after HVACP treatment. (100 ?M) was treated at 85 kV with for 0, 2, 5, 10, 20 min. HepG2 cells were ...

Abstract This investigation was aimed to evaluate the effects of Silybum marianum seed, Thymus vulgaris , and Rosmarinus officinalis powders their combination in alleviating risks aflatoxin B1 (AFB1) young broiler chicks. One-day-old Ross 308 male chickens were allocated 6 experimental groups from d 1 21. The dietary included: Negative control (NC) received basal diet, Positive (PC) containing ...

The current study was to better understand the potential factors affecting aflatoxin B1 (AFB1) accumulation varies between different grains. The nutrient composition and contents of defatted substrates were determined; additionally, according to the nutrient content of the substrates, the effects of starch, soluble sugars, amino acids, and trace elements on AFB1 production and mycelial growth i...

Contamination of food and feed by Aflatoxin B1 (AFB1) is a cause of serious economic and health problems. Different processes have been used to degrade AFB1. In this study, biological degradation of AFB1 was carried out using three Actinomycete species, Rhodococcus erythropolis ATCC 4277, Streptomyces lividans TK 24, and S. aureofaciens ATCC 10762, in liquid cultures. Biodegradation of AFB1 was...

Mycotoxins are toxic fungal metabolites which are structurally diverse, common contaminants of the ingredients of animal feed and human food. To date, mycotoxins with carcinogenic potency in experimental animal models include aflatoxins, sterigmatocystin, ochratoxin, fumonisins, zearalenone, and some Penicillium toxins. Most of these carcinogenic mycotoxins are genotoxic agents with the excepti...

Four major aflatoxins (AFB1, AFB2, AFG1 and AFG2) are direct contaminants of grains and finished feeds. Factors that increase the production of aflatoxins in feeds include environmental temperatures above 270C, humidity level greater than 62%, and moisture levels in the feeds above 14% (Magan and Lacey, 1988; Whitlow and Hagler Jr., 2002). The extent of contamination will vary with geographical...

Chronic hepatitis B virus (HBV) infection and aflatoxin B1 (AFB1) exposure interact synergetically to induce hepatocellular carcinoma. One suggested mechanism for this interaction is the enhanced activation of AFB1 in chronically HBV-infected individuals. Whereas no associations between chronic HBV infection and AFB1albumin adducts were observed in several studies in adults, hepatitis B surface...

The monkey CYP1A1 has been expressed in BALB 3T3 A31-1-1 cells and the expressed proteins were assayed for their capacity to activate aflatoxin B1 (AFB1) and benzo[a]pyrene (B[a]P). The transformed cells were approximately 5.4- and 4.7-fold more sensitive to AFB1 and B[a]P than the parental cells, respectively. These results indicate that monkey CYP1A1 cDNA encoded a functional protein and that...

Deep sequencing was used to investigate the subchronic effects of 1 ppm aflatoxin B1 (AFB1), a potent hepatocarcinogen, on the male rat liver transcriptome prior to onset of histopathological lesions or tumors. We hypothesized RNA-Seq would reveal more differentially expressed genes (DEG) than microarray analysis, including low copy and novel transcripts related to AFB1's carcinogenic activity ...