Thirty chalcone derivatives were synthesized via a base catalyzed Claisen Schmidt condensation and evaluated for their anti-methicillin-resistant Staphylococcus aureus (MRSA) activity alone and in combination with norfloxacin. Among these, 5 derivatives namely trans-3-(1H-indol-3-yl)-1-(40benzyloxyphenyl)-2-propen-1-one (2), 1-(400-biphenyl)-3-(3040-dihydroxyphenyl)-2-propen-1-one (11), 1(400-h...

We have studied the laser spectra from conjugated chalcone in a few organic solutions. The laser of the chalcone appears to arise from its monomeric state. Chalcone in solutions of acetone or tetrahydrofuran (THF) was pumped by the third harmonics of an Nd: YAG (355 nm) for different concentrations and pump-pulse energies.

The first iron(III)/N,N'-dioxide-catalyzed asymmetric haloamination of 3-alkylidene- and 3-arylidene-indolin-2-ones was developed, affording the corresponding chiral oxindole derivatives bearing vicinal haloamine substituents with excellent results (up to 99% yield, 99% ee, >19 : 1 dr). This iron catalyst also exhibits perfect enantioselectivity for chalcone derivatives. The cooperative activat...

Herein we present a photoreactive chalcone moiety that can be synthesized at scale of several grams with ease, and efficiently undergo [2 + 2] photocycloaddition light close to 500 nm as determined by an action plot.