Our previously conducted pharmacological screening led as to the discovery of the strong local anesthetic activity of the compound designated as KP-23. Earlier crystallographic studies revealed that the compound KP-23 crystallized in diastereoisomeric form in lowest symmetry. The aim of these comparative investigations was to evaluate anesthetic activity of KP-23 and its R,S-diastereoisomers, w...

Background: Status of tumor receptor, including estrogen receptor(ER), progesterone receptor(PR) and Erb-B2 Receptor Tyrosine Kinase 2(ERBB2), is important to predict clinical behavior in breast cancer. Cutaneous metastasis from cancer a dismal sign. However, whether the receptor status would differ primary skin metastatic sites conversion affect remain unknown. Methods: From 2002 2021, 41 pati...

we have reviewed the medical records of 40 patients with disseminated (bacille calmette-guerin) bcg from 1996 to 1999 in the immunology department of the children hospital, medical center, tehran university. these patients are divided in to 3 groups: 1. patients who had disseminated (bacille calmette-guerin) bcg after vaccination and their diagnosis was chronic granulomatous disease. 2. patient...

objective(s): we aimed to examine association of gene expression of mor1 and glun1 at mrna level in the lumbosacral cord and midbrain with morphine tolerance in male wistar rats. materials and methods: analgesic effects of morphine administrated intraperitoneally at doses of 0.1, 1, 5 and 10 mg/kg were examined using a hot plate test in rats with and without a history of 15 days morphine (10 mg...

background: the etiology of breast cancer and our understanding on the carcinogenicity of different risk factors is impotant for control programms. objective: we investigated the expression of estrogen and progesterone receptors (er, pr), and human epithelial receptor 2 (her2) overexpression and its associations, with environmental risk factors among breast cancer patients.  methods: we classif...

background: papillary thyroid carcinoma (ptc), occurs mostly in women and sex hormones may play a role in the pathogenesis and clinical course. the objective of this study was to determine the status and prevalence of estrogen and progesterone receptors in ptc with regard to age, gender, tumor size and lymph node involvement. methods: immunohistochemical stains were performed on 92 tissue block...

background: premenstrual dysphoric disorder (pmdd) is a mood disorder characterized with physical and affective symptoms during the luteal phase of susceptible women. objective: the aim of this study was to investigate the association of dopamine d3 receptor ( drd3 ) polymorphism, and cannabinoid receptor type 1 ( cnr1 ) polymorphism with pmdd. materials and methods: fifty one participants with...

Serotonin, like other neuromodulators, acts on a range of receptor types, but its effects also depend on the functional characteristics of the neurons responding to receptor activation. In the inferior colliculus (IC), an auditory midbrain nucleus, activation of a common serotonin (5-HT) receptor type, the 5-HT 1A receptor, depresses auditory-evoked responses in many neurons. Whether these effe...

Tetanic stimulation of the sciatic nerve (TSS) induces sciatic nerve injury and long-lasting pain hypersensitivity in rats, and spinal glial activation and proinflammatory cytokines releases are involved. In the present study, we showed that spinal interleukin (IL)-23 and its receptor, IL-23R, are crucial for the development of mechanical allodynia after TSS. In the spinal dorsal horn, both IL-...

Human genetic associations and transformational efficacy of antibody therapeutics have defined the interleukin (IL)-23 pathway as a pathogenic driver in psoriasis, psoriatic arthritis, inflammatory bowel disease. There are currently no orally delivered selectively targeting this pathway. JNJ-2113 is macrocyclic peptide that binds to IL-23 receptor with high affinity (KD 2 pM), demonstrated pote...