OBJECTIVE To study the effects of the somatostatin analog octreotide on gastric mucosal function and histology during short-term (3 months) preoperative treatment in patients with acromegaly. DESIGN Open design clinical study. METHODS 10 patients were studied before treatment with octreotide (pre-tx), on day 1 of 300 microg octreotide/day (d300), after 1 week on 300 (w300), 600 (w600) or 15...

Abstract Background and Aims Acute kidney injury (AKI) describes a sudden loss of function characterized by elevated serum creatinine (CRE) levels reduced urinary output. AKI patients have high mortality rate, but limited treatment options are currently available. During the progression, an excess reactive oxygen species (ROS) leads to oxidative stress, which often results in cell damage renal ...

The murine plasma cell line MOPC 315 efficiently targets newly synthesized acid hydrolases to lysosomes in spite of a marked deficiency in the level of the mannose 6phosphate receptor (Gabel, C ., D . Goldberg, and S . Kornfeld, 1983, Proc . Nad. Acad . Sci. USA, 80:775-779) . To better understand the routing of lysosomal enzymes in this cell line, pulsechase experiments were performed with [23...

We fabricated an electrode chip with a structure coated by an insulation layer that contains dispersed SiO(2) adsorbent particles modified by an amino-group on a source-drain electrode. Voltage changes caused by chelate molecule adsorption onto electrode surfaces and by specific cation interactions were investigated. The detection of specific cations without the presence of chelate molecules on...

We have investigated the role of the inducible isoform (iNOS) in models of inflammatory and neuropathic hypersensitivity using immunohistochemistry, chemiluminescence and the selective iNOS inhibitor GW274150 (Alderton et al, 2005). Male random hooded rats (200-250g) were used. Freund’s complete adjuvant (FCA): animals received 0.1ml of FCA (1mg/ml) or saline intraplantar into the left hind paw...

Photodynamic therapy (PDT) has recently emerged as an effective, noninvasive, and economical treatment for diseases including cancers. Traditional PDT suffers mainly from having an insufficient number of photons penetrating the tissue and preferentially targeting cancerous tissues with photosensitizers. Therefore, it is necessary to construct a method for controllable singlet-oxygen (O2) genera...

Tacrolimus is a macrolide lactone with potent immunosuppressive properties. It has been shown in clinical studies to prevent allograft rejection. The pharmacokinetics of tacrolimus in healthy subjects and transplant patients has been described in earlier studies using immunoassay methods; however, detailed information on the absorption, distribution, metabolism, and excretion of tacrolimus usin...

Natural products with antioxidant capacity have recently caught the attention of researchers as well as members of the public. In this study, the possible protective effects of green tea and white pepper against oxidative damage induced by H2O2 were investigated on PC12 cells. Neither green tea nor white pepper was able to exert any protective effect. Indeed, green tea enhanced cytotoxicity, so...