Abstract Background 25-hydroxyvitamin D is the recommended target to evaluate vitamin status. The accurate measurement of by liquid chromatography/mass spectrometry (LC/MS/MS) impacted presence biologically inactive epimer D2 and D3, 3-EPI-25-hydroxyvitamin D3. epimers are isomers share same mass fragment transitions as For an should be chromatographically separated from D. Herein we assess sig...

vitamin d is important for the development, growth, and mineralization of the skeletal in neonates and children. vitamin d is essential for intestinal absorption of calcium. vitamin d is metabolized to 25-hydroxyvitamin d and then to 1,25-dihydroxyvitamin d. pregnant women in developed countries often have insufficient serum concentrations of 25-hydroxyvitamin d and a supplementation of vitamin...

Hip fracture has increasingly become a social and economic burden. The relationship between serum 25-hydroxyvitamin D levels and the risk of hip fracture reported by previous studies remains controversial. We searched Pubmed and Embase to identify studies reporting the relationship between serum 25-hydroxyvitamin D levels and risk of hip fracture. Fifteen prospective cohort studies with a total...

CONTEXT Few studies in subjects over 50 yr of age have evaluated the influence of variable doses of vitamin D supplementation on serum 25-hydroxyvitamin D levels. OBJECTIVE We performed a meta-analysis of changes in circulating 25-hydroxyvitamin D level associated with vitamin D supplementation in Caucasian subjects over 50 yr old. DATA SOURCES We conducted a systematic search in literature...

BACKGROUND Chronic pain affects nearly 116 million American adults at an estimated cost of up to $635 billion annually and is the No. 1 condition for which patients seek care at integrative medicine clinics. In our Study on Integrative Medicine Treatment Approaches for Pain (SIMTAP), we observed the impact of an integrative approach on chronic pain and a number of other related patient-reported...

OBJECTIVE To evaluate the 25-hydroxyvitamin D [25(OH)D] concentrations in individuals in the city of São Paulo belonging to different age groups and exhibiting specific behavioral characteristics and to correlate the 25(OH)D concentration with the level of UV radiation (UVR). PATIENTS AND METHODS A total of 591 individuals were included, distributed as follows: 177 were living in institutions...