2. The ¢broblast . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 272 2.1. Lamellipodia as ¢lament factories . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 272 2.2. Ventral stress ¢bre assembly . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 273 2.3. Arcs and dor...

Histone deacetylase (HDAC) inhibitors and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) show promise for the treatment of cancers. The purpose of this study was to examine the molecular mechanisms by which HDAC inhibitor MS-275 sensitizes TRAIL-resistant breast cancer cells in vivo, inhibits angiogenesis and metastasis, and reverses epithelial-mesenchymal transition (EMT). BAL...

In this paper we close the gap between the results of [8] and [9] by showing that there are 11-doilies for vertex sets of size 275; 286; : : : ; 462: In [8] it is shown that there are 11-doilies with vertex size 462; 473; : : : ; 1001; and in [9] it is shown that there are such diagrams with vertex size 231; 242; : : : ; 352: This is the third paper in a series showing that 11-doilies exist for...

polyamide-66(pa66)/caco3 micro- and nano-composites were prepared using a polymer solution method at filler loading of 0, 1, 2 and 3 weight percent. nano-size of caco3 was synthesized by micro-emulsion technique. the material was characterized by xrd, sem, ftir and uv-vis techniques. xrd results of composites suggested that caco3 particles are found in the amorphous phase of the semi-crystallin...

Pluralism’s renaissance, thanks to William Connolly, Chantal Mouffe and others, has established its position as the distinctive voice of late modern democracy. It thus calls for an explicit theory of tragedy to address the antagonisms and enmities it reflects and fosters. Treating Machiavelli, Rousseau, Nietzsche, Weber and Camus as members of a minor (tragic) tradition of thought, I articulate...

This paper examines the planning paradigm shift related to the contested “urban renaissance” mega-project in Downtown Seoul (Korea). Similar to other global cities, over the last few decades, different mega-projects have been successfully implemented in Seoul. These projects have been considered engines for urban renewals and transformation. This paper builds on the analysis of the failure and ...

Abstract BACKGROUND Approximately one third of patients with HER2-positive (+) metastatic breast cancer (MBC) develop brain metastases (BrM). In light discordant control extracranial (ECM) versus BrM for standard-of-care antibody-based therapies these patients, and the frequent use radiation surgical particularly CNS-centric disease, we sought to determine proportion HER2+ MBC who suffered neur...

N-(2-aminophenyl)-4-[N-(pyridine-3yl-methoxy-carbonyl) aminomethyl] benzamide (MS-275) is a second generation histone deacetylase (HDAC) inhibitor with significant anti-tumor efficacy currently in clinical development. We investigated the effect of MS-275 treatment on various colon cancer cell lines, as well as on mouse xenograft models derived from human colorectal cancer. MS-275 exerted stron...

Department of Obstetrics, C.S. Mott Center for Human Growth and Development, Wayne State University, 275 East Hancock, Detroit, MI 48201, USA and Department of Gynecology and Psychology, C.S. Mott Center for Human Growth and Development, Wayne State University, 275 East Hancock, Detroit, MI 48201, USA *Corresponding author: C.S. Mott Center for Human Growth and Development, Wayne State Universi...