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Fibroblastic reticular cells (FRCs) are known to inhabit T cell-rich areas of lymphoid organs where they function to coordinate T cell and dendritic cell interactions. However, in vivo manipulation of FRCs has been limited by a dearth of genetic tools targeting this lineage. Here, using a mouse model to conditionally ablate FRCs, we demonstrate their indispensable role in anti-viral T cell resp...
Conversion of atmospheric N2 into NH3 is one of the most important chemical processes, because ammonia is the industrial and biological precursor to many nitrogen-containing compounds. Large-scale transformation of N2 and H2 into ammonia is performed in industry by the Haber-Bosch process, using “potassium-promoted” porous iron.1 A view of the N2-reducing active site of iron-molybdenum nitrogen...
Two different mRNA isoforms of the mouse Soxl 7 gene were isolated from adult mouse testis cDNAs. One form (referred to as form Sox17) encodes an Styrelated protein of 419 amino acids containing a single high mobility group box near the NH2 terminus, while the other form (referred to as form t-Sox17) shows a unique mRNA isoform of the Soxl 7 gene with a partial deletion of the HMG box region. A...
Tumor-associated macrophages (TAMs) promote tumor progression. The number of infiltrating TAMs is associated with poor prognosis in esophageal squamous cell carcinoma (ESCC) patients; however, the mechanism underlying this phenomenon unclear. cDNA microarray analysis indicates that expression chemokine (C-C motif) ligand 1 (CCL1) up-regulated peripheral blood monocyte–derived stimulated using c...
Pantoea stewartii WceF is a glycan biofilm-modifying enzyme with a bacteriophage tailspike-like fold
Pathogenic microorganisms often reside in glycan-based biofilms. Concentration and chain length distribution of these mostly anionic exopolysaccharides (EPS) determine the overall biophysical properties a biofilm result highly viscous environment. Bacterial communities regulate this state via intracellular small-molecule signaling to initiate EPS synthesis. Reorganization or degradation glycan ...
The OncoScan CNV Plus Assay (OS+) is a single-nucleotide polymorphism microarray platform that can detect 74 hotspot somatic mutations (SMs) in nine genes via molecular inversion probes. We report validation of the SM component OS+ using cohort pediatric high-grade brain tumor specimens. calls were generated from 46 cases, most tested orthogonally bidirectional Sanger sequencing. initial callin...
The three-dimensional structure of 132microglobulin, the light chain of the major histocompatibility complex class I antigens, has been determined by x-ray crystallography. An electron density map of the bovine protein was calculated at a nominal resolution of 2.9 A by using the methods of multiple isomorphous replacement and electron density modification refinement. The molecule is approximate...
•High-glucose-induced ROS promotes phosphorylation of AMPKα at S485/491 by AKT•Phosphorylation is required for recruitment E3 ligase MG53•MG53 mediates skeletal muscle ubiquitination and subsequent degradation•High glucose also deactivates inducing disassociation from LKB1 As a master regulator metabolism, AMP-activated protein kinase (AMPK) activated upon energy shortage but suppressed overnut...
The volatiles emitted by agar plate cultures of the xylarialean fungus Hypoxylon invadens were investigated by use of a closed loop stripping apparatus in combination with GC–MS. Several aromatic compounds were found that could only be identified by comparison to all possible constitutional isomers with different ring substitution patterns. For the set of identified compounds a plausible biosyn...
Understanding the mechanisms that contribute to the sensory recognition ofdietary fat has become increasingly important given the epidemic of obesity which ispartially driven by high dietary fat intake. While the textural properties of dietary fat (e.g.triglycerides) have been well documented to occur via the activation of trigeminalganglionic neurons (TGNs) in the somatosen...
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