an efficient construction of 2-(n-arylamino)benzaldehydes and n-aryl-3,10-dihydroacridin-1(2h)-one derivatives starting from 2- hydroxybenzaldehydes has been developed. the synthesis of n-aryl-3,10-dihydroacridin-1(2h)-ones is based on the knoevenagel condensation of dimedone to various 2-(n-arylamino)benzaldehydes, followed by an intramolecular enamination in the presence of 20 mol% of nanocry...

10-((4-Hydroxypiperidin-1-yl)methyl)chromeno[4,3,2-de]phthalazin-3(2H)-one (E7016), an inhibitor of poly(ADP-ribose) polymerase, is being developed for anticancer therapy. One of the major metabolites identified in preclinical animal studies was the product of an apparent oxidation and ring opening of the 4-hydroxypiperidine. In vitro, this oxidized metabolite could not be generated by incubati...

In the title compound, C(9)H(8)O(2), a benzo-annulated heterocyclic ketone, the non-aromatic six-membered ring adopts an E(2) conformation. In the crystal, C-H⋯O contacts connect the mol-ecules into double sheets perpendicular to the crystallographic a axis. The centroid-centroid distance for two π-systems is 3.7699 (6) Å.

Pathogenic fungi are one of the main causes of hospital-related infections. Since conventional antifungals have become less effective because of the increasing fungal resistance to the standard drugs, the need for new agents is becoming urgent. Herein we report a synthesis of a series of novel N-[imino-(1-oxo-(1H)-phthalazin-2-yl)methyl]-benzenesulfonamide derivatives with in vitro activity aga...