PDK1 phosphorylates multiple substrates including Akt by PIP3-dependent mechanisms. In this report we provide evidence that in prostate cancer cells stimulated with activated α2-macroglobulin (α2M*) PDK1 phosphorylates Akt in the T-loop at Thr(308) by using Raptor in the mTORC1 complex as a scaffold protein. First we demonstrate that PDK1, Raptor, and mTOR co-immunoprecipitate. Silencing the ex...

OBJECTIVE To evaluate the potential effects of a 308-km ultra-marathon on bone and cartilage biomarkers. METHOD Venous blood samples were collected at pre-race, 100 km, 200 km, and 308 km checkpoints. The following markers of cartilage damage and bone metabolism were studied: osteocalcin (OC), osteoprotegerin (OPG), and calcium, phosphorous, and cartilage oligomeric matrix protein (COMP). R...

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BACKGROUND Recent reports show that 308-nm excimer laser may be an effective and safe method for the treatment of vitiligo, which is usually resistant to other available treatment methods. OBJECTIVE The objective was to study the effectiveness of the new 308-nm excimer laser for the treatment of vitiligo. METHODS A retrospective chart review of thirty-two patients with 55 spots of vitiligo ...

OBJECTIVE Our purpose was to demonstrate the efficacy of the 308-nm excimer laser for treatment of psoriasis. METHODS This study was a multicenter open trial from 5 dermatology practices (one university-based and 4 private practices). Up to 30 patients per center with stable mild to moderate plaque-type psoriasis constituted the study population. Patients received 308-nm ultraviolet B doses t...

Y. H. Li, T. Liu, Q. Du, J. Sun, Y. Xia, Z. Wang, W. Zhang, K. Wang, H. Zhu, and D. Wu Laboratory of Fiber Materials and Modern Textile, the Growing Base for State Key Laboratory, Qingdao University, 308 Ningxia Road, Qingdao 266071, China College of Electromechanical Engineering, Qingdao University, 308 Ningxia Road, Qingdao 266071, China Key Laboratory for Advanced Manufacturing by Material P...

Abstract Linked Article: Goulden et al. Br J Dermatol 2022; 187:295–308.

We present a meta-analysis of independent studies on the potential implication in the occurrence of coronary heart disease (CHD) of the single-nucleotide polymorphism (SNP) at the -308 position of the tumor necrosis factor alpha (TNF-alpha) gene. We use Bayesian analysis to integrate independent data sets and to infer statistically robust measurements of correlation. Bayesian hypothesis testing...

The present study was performed to investigate the effect of retinoic acid amide (RAA) on the expression of integrin α3β1, rate of cell proliferation and migration in p53-deficient glioma cell line, LN-308. The results revealed promotion of integrin α3 expression, reduction in proliferation and migration in RAA treated cells compared to the control LN-308 glioma cells. Promotion of RAA induced ...