Significance: Organozinc compounds are very useful intermediates in synthesis of complex organic molecules due to their high reactivity combined with an excellent tolerance of functional groups. So far, the direct insertion of commercial zinc dust into organic halides was limited only to alkyl iodides and tertiary bromides, which diminished its synthetic value. Herein, a new method, allowing th...

AIMS Matrix metalloproteinase stromelysin-1 has been implicated in the process of exaggerated lumen re-narrowing after primarily successful interventions in coronary arteries. We examined the possibility that the 5A/6A promoter polymorphism of the stromelysin-1 gene is associated with restenosis after stenting or percutaneous transluminal coronary angioplasty (PTCA). METHODS AND RESULTS The s...

Microsphere Based Liquid Array 2 3 John R. McQuiston * , R. Jordan Waters, Blake A. Dinsmore, Matthew L. Mikoleit, and 4 Patricia I. Fields 5 Enteric Diseases Laboratory Branch, Division of Foodborne Waterborne and 6 Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. 7 8 9 10 Running Title: Molecular Determination of the H-antigens of Salmonella. 11 Correspond...

Intelligibility is one of the key factors affecting the acceptance and effective use of information systems. In this article, we discuss the ways in which recognition of this factor challenges current system design strategies, as well as current theoretical perspectives and research methodologies. In particular, we claim that in order to understand the problem of system intelligibility, we must...

ion In Action I want to start by talking about the current view of abstraction in software engineering: how we use it, what the principles are, what the terminology is and what it does for us. Rather than attempting any sort of formal definition, I will just use an example. I will talk about the implementation of a familiar system, using familiar terms of abstraction, with the goal of getting t...

We have previously demonstrated that the subcellular distribution of the adhesion plaque protein, talin, changes dramatically in human platelets in response to platelet activation (Beckerle et al., J. Cell Biol. 109, 3333-3346, 1989). Talin is uniformly distributed throughout the cytoplasm of resting platelets. However, when platelets are stimulated to become activated and adhesive, a significa...

Fine-needle aspiration biopsy cytology (FNABC) and ultrasonography (US) play an important role in differentiating benign thyroid nodules from malignant nodules. We retrospectively investigated the prevalence of follicular thyroid carcinoma (FTC) in patients with thyroid nodules whose FNABC and US readings were not malignant before thyroidectomy. Between 2007 and 2008, 3333 patients underwent th...

Traditionally, network communication entailed the delivery of messages to specific network addresses. As computers acquired multimedia capabilities, new applications such as video broadcasting dictated the need for real-time quality of service guarantees and delivery to multiple recipients. In light of this, a subtle transition took place as a subset of IP addresses evolved into a group-naming ...

Macrothrombocytopenia in MYH9-related disease (MYH9-RD) results from defects in nonmuscular myosin-IIA function. Thrombopoietin receptor agonists (eltrombopag; romiplostim) seem to improve hemostasis, but little is known about their biologic effects in MYH9-RD. We administered romiplostim to Myh9 / mice (100 g/kg, every 3 days, during 1 month). MKs increased to similar numbers in Myh9 / and wil...

BACKGROUND Cervical cancer is the most frequent cancer of women in Latin America, being strongly associated with infection by certain human papillomavirus (HPV) types. Familial cancer clustering can be due to interactions between infectious agents and host genes. MATERIALS AND METHODS A cancer-related family history of first degree relatives was elicited in 335 women with invasive cervical ca...