Puroose: Proliferative diabetic retinopathy is assumed to develop because vasogenic factors are released from retinal areas that are ischaemic and hypoxic secondary to occlusion of the retinal vascular bed. It has been propclsed that vascular occlusion in diabetic retinopethy may be due to the deposition of periodic acid Schiff positive glycoprotein compounds in the retinal vascular walls. but ...

Abstract We present observations of an extreme radio flare, VT J024345.70-284040.08, hereafter J0243, from the nucleus a galaxy with evidence for historic Seyfert activity at redshift z = 0.074. Between NRAO Very Large Array (VLA) Sky Survey in 1993 to VLA 2018, J0243 rose ∼ GHz luminosity ν L ≲ 10 38 erg s −1 40 , and still continues brighten. The spectral energy distribution evolution is cons...

BACKGROUND Iosimenol 340 injection is a new isotonic iodinated contrast medium for X-ray angiography. PURPOSE To investigate the pharmacokinetics and biotransformation, tolerability, and safety of Iosimenol 340 in healthy human subjects. MATERIAL AND METHODS Twenty-four subjects were enrolled and randomized to receive either Iosimenol 340 (0.5, 1.5 or 3.0 mL/kg) or placebo (0.9% saline). In...

A two player game (or more correctly, a two player normal-form game) is specified by two m × n payoff matrices R and C corresponding to the row and column player respectively. Each of these matrices has m rows corresponding to the m strategies of the row player and n columns corresponding to the n strategies of the column payer. The row player picks a row i ∈ [m], and the column player picks a ...

Salivary agglutinin is a high molecular mass component of human saliva that binds Streptococcus mutans, an oral bacterium implicated in dental caries. To study its protein sequence, we isolated the agglutinin from human parotid saliva. After trypsin digestion, a portion was analyzed by matrix-assisted laser/desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS), which gave the mo...

Colorectal cancer represents one of the most challenging diseases. Increasing evidence indicates that aberrant expression of microRNAs (miRNAs) is related to pathogenesis of colorectal cancer. Cancer cells reprogram metabolic pathways to sustain higher proliferation rates. Whether mechanisms underlying the role of miRNA in colorectal cancer are in...

The effect of cysteamine, a specific somatostatin depletor, on biliary secretion was studied in urethane-anesthetized rats. Different groups of rats received ip cysteamine at 25, 100 or 340 mg/kg just before bile collection commenced. Other groups of rats were pretreated with cysteamine (340 mg/kg ip) at 4 or 24 h prior to bile duct cannulation and bile collection. Bile secretions were collecte...

Abstract Background Radiotherapy resistance is a major obstacle in the treatment of oesophageal squamous cell carcinoma (OSCC). Hypoxia critical cause radioresistance. However, communication between hypoxic cells and aerobic via exosomes during transfer radiation remains unclear. Methods Exo-miR-340-5p levels were analysed by RNA-seq qRT-PCR. We co-cultured OSCC with isolated normoxic to study ...