Studies of the meiotic distribution of compound-3 chromosomes in males and females of Drosophila melanogaster provided the following results. (1) From females homozygous for the standard arrangement of all chromosomes other than C(3L) and C(3R), less than 5% of the gametes recovered were nullosomic or disomic for compound-3 chromosomes. The frequency of nonsegregation differed between strains, ...

OBJECTIVE To estimate the willingness to pay (WTP) per quality-adjusted life year (QALY) value for life-saving treatments and to determine factors affecting the WTP per QALY value. DESIGN A cross-sectional survey with multistage sampling and face-to-face interviews. SETTING General population in the southern part of Thailand. PARTICIPANTS A total of 600 individuals were included in the st...

Purpose: This study evaluated the validity of 8-item Health-Related Quality Life (HINT-8) instrument for older adults in Korea. Methods: used data from 2019 Korean National Health and Nutrition Examination Survey. Health-related quality life distribution ceiling effect were investigated using HINT-8 EuroQol-five-dimensions three-level version (EQ-5D-3L) 1,519 people aged 65 or To examine known-...

The paradoxical coexistence of spontaneous tumor antigen-specific immune responses with progressive disease in cancer patients furthers the need to dissect the molecular pathways involved in tumor-induced T cell dysfunction. In patients with advanced melanoma, we have previously shown that the cancer-germline antigen NY-ESO-1 stimulates spontaneous NY-ESO-1-specific CD8(+) T cells that up-regul...

The synthesis and characterization of trinuclear Ge and Sn chlorides and a trialuminum complex supported by a trinucleating tris(β-diketiminate) cyclophane ligand (L3−) are reported. The in situ deprotonation of H3L with benzylpotassium and subsequent reaction with GeCl2·dioxane or SnCl2 afforded (GeCl)3L (1) and (SnCl)3L (2) in 42 and 60% yields, respectively. Each Ge and Sn atom is three-coor...

EQ-5D is used in cost-effectiveness studies underlying many important health policy decisions. It comprises a survey instrument describing health states across five domains, and a system of utility values for each state. The original 3-level version of EQ-5D is being replaced with a more sensitive 5-level version but the consequences of this change are uncertain. We develop a multi-equation ord...

This paper addresses a Three-Dimensional Loading Capacitated Vehicle Routing Problem (3L-CVRP) which combines a three-dimensional loading problem and vehicle routing problem in distribution logistics. The problem requires the combinatorial optimization of a feasible loading solution and a successive routing of vehicles to satisfy client demands, where all vehicles must start and terminate at a ...

In this paper we extend the recently developed third-order limiter function H 3L [J. Sci. Comput., (2016), 68(2), pp. 624–652] to make it applicable for more elaborate test cases in the context of finite volume schemes. This work covers the generalization to non-uniform grids in one and two space dimensions, as well as two-dimensional Cartesian grids with adaptive mesh refinement (AMR). The ext...

We investigate a lattice construction method for the Coppersmith technique for finding small solutions of a modular equation. We consider its variant for simultaneous equations and propose a method to construct a lattice by combining lattices for solving single equations. As applications, we consider a new RSA cryptanalyses. Our algorithm can factor an RSA modulus from l ≥ 2 pairs of RSA public...