material (4 ). It appears that intermittent interferences from Hb C and S traits with some, but not all, ionexchange GHb methods continues to be an issue. In summary, some current GHb methods show clinically significant interferences with samples containing Hb C or S trait. These interferences are not necessarily consistent within method types, and with ion-exchange methods may vary over time w...

γ-Hydroxybutyric acid (GHB) is an endogenous compound and a drug used clinically to treat the symptoms of narcolepsy. GHB is known to be an agonist of GABAB receptors with millimolar affinity, but also binds with much higher affinity to another site, known as the GHB receptor. While a body of evidence has shown that GHB does not bind to GABAA receptors widely, recent evidence has suggested that...

We describe a novel assay for measuring glycohemoglobin directly from anticoagulated whole blood with the Abbott IMx analyzer. The glycohemoglobin is labeled with a soluble polyanionic affinity reagent and the anionic complex is then captured with a cationic solid-phase matrix. Glycohemoglobin is quantified by measuring the quenching by heme of the static fluorescence from an added fluorophore....

From June 1998 to May 2007, 9566 urine samples were collected from patients with psychomotor deficits, seizures, vomiting and unconsciousness in Peking University First Hospital. Their urine organic acids profiles were analysed using gas chromatography - mass spectrometry (GCMS), GCMS solution and Inborn Errors of Metabolism Screening System software. In all patients, blood acylcarnitines were ...

In this paper, we describe a distinct clinical subtype of 3-methylglutaconic aciduria. 3-Methylglutaconic aciduria is a group of different metabolic disorders biochemically characterized by increased urinary excretion of 3-methylglutaconic acid. We performed biochemical and genetic investigations, including urine organic acid analysis, NMR spectroscopy, measurement of 3-methylglutaconyl-CoA hyd...

The case of an 8-year-old boy complaining easy tiredness, poor exercise tolerance and high CPK blood level is described. diagnosis glutaric aciduria type II was finally made.

An accurate, simple colorimetric method for the determination of serum alpha-hydroxybutyric dehydrogenase activity is described. The method is suitable for routine laboratory use.

UFT, an anticancer agent that is composed of tegafur (FT) and uracil at a molar ratio of 1:4, is widely used in clinical practice in Japan to treat cancer patients requiring a long-term chemotherapy, and it is associated with few side effects, if any. In this study, we have evaluated the inhibitory effect of UFT against RENCA cell-induced angiogenesis by a dorsal air sac assay. Marked angiogene...

Abstract The effects of NaCl, Na 2 SO 4 , HPO and 3 C 6 H 5 O 7 on the production 3-hydroxybutyrate, polyhydroxybutyrate, by-products by Burkholderia cepacia . Proper addition can significantly promote 3-hydroxybutyric acid polyhydroxybutyrate. concentration, productivity, yield 3-hydroxybutyrate were increased 48.2%, 55.6%, 48.3% at 16 mM increases 80.1%, 47.1%, 80.0% in polyhydroxybutyrate ob...