نتایج جستجو برای: 4 hydroxycoumarin
تعداد نتایج: 1303773 فیلتر نتایج به سال:
Coumarin derivatives are an important class of C6-C3 plant metabolites that show a variety of bioactivities. Currently, most clinical anticoagulant agents are coumarins, such as warfarin, dicoumarol and acenocoumarol, and patients taking these drugs must be monitored for adverse reactions. In a search for safe and effective anticoagulant compounds from Chinese herbal medicine, a screening proce...
The new 4-amino-2-(p-tolyl)-7H-chromeno[5,6-d]oxazol-7-one was successfully prepared through the Au/TiO2-catalyzed NaBH4 activation and chemoselective reduction of 4-nitro-2-(p-tolyl)-7H-chromeno[5,6-d]oxazol-7-one. latter synthesized by one-pot tandem reactions 6-hydroxy-5,7-dinitrocoumarin with p-tolylmethanol under Au/TiO2 catalysis. dinitrocoumarin obtained nitration 6-hydroxycoumarin ceriu...
Malonyl-CoA is the building block for fatty acid biosynthesis and also a precursor to various pharmaceutically and industrially valuable molecules, such as polyketides and biopolymers. However, intracellular malonyl-CoA is usually maintained at low levels, which poses great challenges to efficient microbial production of malonyl-CoA derived molecules. Inactivation of the malonyl-CoA consumption...
The purpose of this study was to examine in vivo the activity of cytochrome P450 (CYP) 2A6, an enzyme capable of activating carcinogens, including N-nitrosodimethylamine, in humans with the carcinogenic liver fluke infection, opisthorchiasis viverrini, before and after treatment with the antiparasitic agent, praziquantel. Coumarin hydroxylase activity of CYP 2A6 was assessed by administering a ...
Density functional calculations with Becke’s three parameter hybrid method using the correlation functional of Lee, Yang and Parr (B3LYP) were carried out for 3,30-benzylidenebis(4-hydroxycoumarin) (phenyldicoumarol, PhDC), 3,30-methylenebis(4-hydroxycoumarin) (dicoumarol, DC) and the parent compound, 4-hydroxycoumarin (4-HC). Different basis sets were tested in the course of the calculations: ...
C2-symmetric diimine generated in situ from (R,R)-HPEN and 8-formylquinoline was readily transformed to novel chiral pre-III bearing 1(S),2(S)-bis(quinolin-8-yl) ethane salicylic aldehyde fragments via stereoselective diaza-Cope rearrangement. The structure absolute configuration of the product established by X-ray diffraction study corresponding Rh(III) complex. In presence pre-III, practicall...
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