Enteric coated formulations protect drugs from degrading in the harsh environment of the stomach (acidic pH and enzymes), and promotes drug delivery to and absorption into the duodenum and/or later parts of the intestine. Four DoE models were applied to optimize formulation parameters for the preparation of pH sensitive nifedipine nanoparticles. Stability studies were performed on the optimized...

The Pythagorean-hodograph curves offer unique computational advantages in computer aided design and manufacturing. In this paper, geometric parameters based cubic PH curve interpolation and approximation algorithms are presented. The essential geometric parameters include the ratio ρ of the adjacent control polygon legs, the control polygon angle θ, the first control polygon leg L, the included...

AIM To determine the risk of developing acute bronchial spasm and bronchial hyperreactivity in healthy subjects after inhaling hydrochloric acid aerosol of different pH, since various characteristics of inhaled aerosol, particularly its acidity, contribute to the reduction in lung function in patients with a pre-existing disease. METHODS Randomized, double-blind, placebo-controlled trial incl...

1. I N T R O D U C T I O N Rational parametrization of curves and surfaces is a very interesting problem in mathematics. For curves, it is shown that a curve of genus zero is a rational by Noether. As for surfaces, there is Noether 's theorem that an algebraic surface S is rational if and only if it contains an irreducible rational curve C with dim ICI >1. Although there exist some techniques t...

Background Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] is an important regulator of several cellular processes and a precursor for other second messengers which are involved in cell signaling pathways. Signaling proteins preferably interact with PI(4,5)P2 through its pleckstrin homology (PH) domain. Efforts are underway to design small molecule-based antagonist, which can specifically inh...

This study reports the capacities and mechanisms of live biomass of an ascomycetes strain, Aspergillus niger HM11 biomass preparations in removing a textile dye Reactive blue 140 from aqueous solution was investigated with different parameters, such as adsorbent dosage, pH, initial dye concentrations and equilibrium time. pH study and desorption profile proved that adsorption process was suppor...

4-N-trimethylaminobutyraldehyde dehydrogenase from Pseudomonas sp. 13CM was purified 14-fold to apparent homogeneity by hydrophobic chromatography on a Phenyl-Toyopearl, and affinity chromatography was done on a 5'-AMP Sepharose4B in the presence of dithiothreitol. The enzyme was found to be a trimer with identical 55 kDa subunits. The isoeletric point was found to be 5.5. The optimum temperatu...

This study was aimed to determine chemical and physical characteristics of extracted tilapia fish bone gelatin using acid (HCl) alkaline (NaOH) solutions. The research method used comparative experimental with Paired t-test consisting 2 treatments, namely 4% HCl NaOH 3 replications. Analysis parameters consisted yield, gel strength, viscosity, pH, moisture content, ash. Characteristics solution...

Decolorization of sunset yellow dye (SY) in an aqueous solution was investigated by Fenton reaction using H2O2/Fe 2+ system. Different parameters controlling the degradation efficiency as pH and H2O2 and Fe 2+ concentrations were evaluated. The optimal operational conditions were found to be [Fe] = 2.55x10 mmol, [H2O2] = 0.2425 mmol at pH 2.7. The study of the Kinetics of decolorization indicat...

BACKGROUND In this research, the removal of natural organic matter from aqueous solutions using advanced oxidation processes (UV/H2O2) was evaluated. Therefore, the response surface methodology and Box-Behnken design matrix were employed to design the experiments and to determine the optimal conditions. The effects of various parameters such as initial concentration of H2O2 (100-180 mg/L), pH (...