CYTOCHROME P450 2E1 – RELEVANCE FOR CENTRAL DOPAMINE NEUROTRANSMISSION AND PARKINSON’S DISEASE Haydeh Niazi Shahabi Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Box 431, SE-405 30, Göteborg,

Analysis and Performance of Iterative Source-Channel Decoding Norbert Görtz Faculty of Engineering, University of Kiel, Kaiserstr. 2, 24143 Kiel / Germany Tel: +49 431 77572 406, Fax: +49 431 77572 403 E-mail: [email protected] Abstract: A new iterative source-channel decoding technique is proposed, which approximates optimal joint source-channel decoding for the channel-encoded quantizer...

BACKGROUND Mutations in the leucine-rich, glioma-inactivated 1 (LGI1) gene have been implicated in autosomal dominant lateral temporal epilepsy. OBJECTIVE To describe the clinical and genetic findings in 2 families with autosomal dominant lateral temporal epilepsy and the functional consequences of 2 novel mutations in LGI1. DESIGN Clinical, genetic, and functional investigations. SETTING...

We report the crystal structure of a binary complex of human peroxisomal carnitine acetyltransferase and the substrate l-carnitine, refined to a resolution of 1.8 Angstrom with an R(factor) value of 18.9% (R(free)=22.3%). L-carnitine binds to a preformed pocket in the active site tunnel of carnitine acetyltransferase aligned with His(322). The quaternary nitrogen of carnitine forms a pi-cation ...

Wenjie Gong, Guangming Xiong, Edmund Maser* 5 6 Institute of Toxicology and Pharmacology for Natural Scientists, University Medical School, Schleswig7 Holstein, Campus Kiel, Brunswiker Strasse 10,D-24105 Kiel, Germany 8 9 *Corresponding author: Prof. Edmund Maser, Tel.: +49-431-597-3540; fax: +49-431-597-3558; 10 E-mail address: [email protected] (E. Maser) 11 12 Running Title: HsdR positi...

Novel 2-deoxo-2-phenyl-5-deazaflavins and 2-deoxo-2-phenylflavin-5-oxides were prepared as a new class of antitumor agents and showed significant antitumor activities against NCI-H 460, HCT 116, A 431, CCRF-HSB-2, andKB cell lines. In vivo investigation, 2-deoxo-10-methyl-2-phenyl-5-deazaflavin exhibited the effective antitumor activity against A 431 human adenocarcinoma cells transplanted subc...

Sulphite inhibited growth of all four yeasts studied, Zygosaccharomyces bailii NCYC 563 being most sensitive and Saccharomyces cerevisiae NCYC 431 the least. Vertical Woolf-Eadie plots were obtained for initial velocities of 35S accumulation by all four yeasts suspended in high concentrations of sulphite. Equilibrium levels of 35S accumulation were reached somewhat faster with strains of S. cer...

Germline nonautoimmune hyperthyroidism due to an activating mutation in the thyroid stimulating hormone receptor gene is an uncommon disease. To date 32 different mutations have been described. The severity of the hyperthyroid symptoms is variable and phenotype differences have been described in subjects harboring the same mutation. This paper describes a family with a mutation in codon 431 of ...

In this letter we develop a new method of blind source separation that is not sensitive to additive white noise. Our method exploits the nonstationarity and temporal structure of sources. The method needs only multiple time-delayed correlation matrices of the observed data at several di erent time-windowed data frames to estimate the mixing matrix. The implementation using joint diagonalization...

«Si autem modus entis accipiatur... secundum convenientiam unius entis ad aliud, hoc quidem non potest esse nisi accipiatur aliquid quod natum sit convenire cum omni ente: hoc autem est anima, quae ‘quodammodo est omnia’ (De An. 431 b 31). In anima autem est vis cognitiva et appetitiva. Convenientiam ergo entis ad appetitum exprimit bonum;... ad intellectum exprimit verum. If the mode of being ...