نتایج جستجو برای: 447 and 499
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COVID-19 has prompted widespread self-isolation and citywide/countrywide lockdowns. The World Health Organisation (WHO) encouraged increased digital social activities such as video game play to counteract isolation during the pandemic. However, there is active debate about potential for overuse, some games contain randomised purchases (loot boxes) that may psychologically approximate gambling. ...
BACKGROUND AQ4N (1,4-bis[[2-(dimethylamino)ethyl] amino]-5,8-dihydroxyanthracene-9, 10-dione bis-N-oxide dihydrochloride) is a prodrug which is selectively activated within hypoxic tissues to AQ4, a topoisomerase II inhibitor and DNA intercalator. PATIENTS AND METHODS In the phase I study, 22 patients with oesophageal carcinoma received an i.v. infusion of AQ4N (22.5-447 mg/m(2)) followed, 2 ...
Mitogen-activated protein kinases (MAPKs) control neuronal synaptic function; however, little is known about the synaptic substrates regulated by MAPKs. A phosphopeptide library incorporating the MAPK consensus motif (PX(pS/pT)P where pS is phosphoserine and pT is phosphothreonine) was used to raise a phosphospecific antibody that detected MAPK-mediated phosphorylation. The antibody (termed "55...
لقد أخذ مفهوم (الآخَر) مدياته من خلال الاتساع بمرور الزمن وتطور المجتمعات والمفاهيم العامة، فهو أعمق القول: "هذا آخَرُ، وهذه أُخْرَى"([i])، أو "بمعنى غَيْر"([ii])، بل بدأ يأخذ أصناف شتى حتى قيل: إنه "عدة أصناف، منه مَنْ يختلف في الدين، وفي العرق، اللون، المستوى الاجتماعي كالفقير والخادم والجارية وغيرهم"([iii])، مقاييس مختلفة "داخلية كالنساء بالقياس إلى الرجال، والفقراء الأغنياء، خارجية المجتمع بصورة أعم"...
BACKGROUND Small RNA molecules, called microRNAs, freely circulate in human plasma and correlate with varying pathologies. In this study, we explored their diagnostic potential in a selection of prevalent cardiovascular disorders. METHODS AND RESULTS MicroRNAs were isolated from plasmas from well-characterized patients with varying degrees of cardiac damage: (1) acute myocardial infarction, (...
The effects of long-term physical inactivity on the expression of microRNAs involved in the regulation of skeletal muscle mass in humans are largely unknown. MicroRNAs are short, noncoding RNAs that fine-tune target expression through mRNA degradation or by inhibiting protein translation. Intronic to the slow, type I, muscle fiber type genes MYH7 and MYH7b, microRNA-208b and microRNA-499-5p are...
AIMS Circulating microRNAs (miRNAs) may represent a novel class of biomarkers; therefore, we examined whether acute myocardial infarction (MI) modulates miRNAs plasma levels in humans and mice. METHODS AND RESULTS Healthy donors (n = 17) and patients (n = 33) with acute ST-segment elevation MI (STEMI) were evaluated. In one cohort (n = 25), the first plasma sample was obtained 517 ± 309 min a...
BACKGROUND MicroRNAs (miRs) negatively regulate transcription and are important determinants of normal heart development and heart failure pathogenesis. Despite the significant knowledge gained in mouse studies, their functional roles in human (h) heart remain elusive. METHODS AND RESULTS We hypothesized that miRs that figure prominently in cardiac differentiation are differentially expressed...
هدف این پژوهش بررسی اثر تمرین استقامتی بر بیان mir-499 بطن چپ بود. بدین منظور 14 رت تحت شرایط کنترل شده (دما، چرخه روشنایی و تاریکی و دسترسی آزاد به آب و غذا) نگهداری و بعد از آشناسازی با پروتکل تمرینی به صورت تصادفی به دو گروه کنترل و تجربی تقسیم شدند. گروه تجربی یک برنامه استقامتی 14 هفته ای را روی تردمیل اجرا کرد و سپس 48 ساعت پس از پایان آخرین جلسه تمرینی بی هوش و تشریح شدند، سپس قلب آنها خ...
Telomerase is expressed in the neonatal brain, in distinct regions of adult brain, and was shown to protect developing neurons from apoptosis. Telomerase reactivation by gene manipulation reverses neurodegeneration in aged telomerase-deficient mice. Hence, we and others hypothesized that increasing telomerase expression by pharmaceutical compounds may protect brain cells from death caused by da...
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