Parenteral vaccination of BALB/c mice primed by infection with H3N2 variants of influenza A virus results in a reduced production of N2 antibody in response to homologous (H3N2) vaccine compared with the response to an H7N2 vaccine equal in N2 immunologenicity. We now have studied the interaction in vitro of purified splenic B and T lymphocytes from variably immunized mice to ascertain the cell...

T cell tolerance to parenchymal self-antigens is thought to be induced by encounter of the T cell with its cognate peptide-major histocompatibility complex (MHC) ligand expressed on the parenchymal cell, which lacks appropriate costimulatory function. We have used a model system in which naive T cell receptor (TCR) transgenic hemagglutinin (HA)-specific CD4+ T cells are adoptively transferred i...

Monoclonal antibody HT462 recognizes a human T-cell leukemia virus type I (HTLV-I)-associated Mr 52,000 glycoprotein (HA-gp52), which is found on the surface of HTLV-infected cells. Whether HA-gp52 is encoded by the virus or by the infected cells has not yet been established. Using monoclonal HT462 in a competitive binding assay, natural human antibodies specific for HA-gp52 were detected in 97...

The polymorphic minor histocompatibility Ag HA-1 locus encodes two peptides, HA-1(H) and HA-1(R), with a single amino acid difference. Whereas the immunogenicity of the HA-1(R) allele has not yet been shown, the nonameric HA-1(H) peptide induces HLA-A2-restricted cytotoxic T cells in vivo and in vitro. It is not known whether the mHag HA-1(H) or HA-1(R) associates with other HLA class I molecul...

An Ultic Haploxeralf soil collected from ridges built into the slopes of the Coastal Mountain Range of Central Chile was used in applications of humic and fulvic acids (HFA) extracted from sludge from sewage treatment plants, in combination with gypsum (CaSO4). A total of 12 treatments were applied by combining four doses of HFA (0, 20, 30 and 40 t ha-1) with three doses of gypsum (0, 1.2 and 6...

CONTEXT Polycystic ovary syndrome (PCOS) is a triad of anovulation, insulin resistance, and hyperandrogenism. Androgen excess may correlate with metabolic risk and PCOS consensus criteria define androgen excess on the basis of serum T. Here we studied the utility of the androgen precursor serum androstenedione (A) in conjunction with serum T for predicting metabolic dysfunction in PCOS. PATIE...

The experiment was conducted at Sher-e-Bangla Agricultural University farm, Dhaka, Bangladesh during the period from March to June 2007 with seven treatments viz; T1: Hand picking of infested fruits of bitter gourd at 7 days interval; T2: Neem seed kernel at 5 gm/l of water at 5 days interval +T1; T3: Spray of shobicron 425EC @ 2ml/l of water at 7 days interval + T1; T4: Micronutrient-Zn @ 6.72...