Although anion-binding processes are well-known for their crucial role in molecular recognition, they have only recently been utilized catalysis. Herein, a new class of chiral, enantiopure C2-symmetrical thioureas that, combination with 4-methoxybenzoic acid, promotes the enantioselective protio-Pictet-Spengler reaction to provide unprotected tetrahydro-?-carbolines good yields (40–93 %) and mo...

A new series of 1,2-diaryl-4,5,6,7-tetrahydro-1H-benzo[d]imidazoles, possessing trimethoxy phenyl pharmacophore, were synthesized to evaluate their biological activities as tubulin inhibitors. Cytotoxic activity of the synthesized compounds 7a-f was assessed against several human cancer cell lines, including MCF-7 (breast cancer cell), HEPG2 (liver hepatocellular cells), A549 (adenocarcinomic h...

The series of 6,7,8,9-tetrahydro-5H-5-(2'-hydroxyphenyl)-2-(4'-substituted benzylidine)thiazolo(2,3-b)quinazolin-3(2H)-ones (4a-j) and 6,7,8,9-tetrahydro-5H-5-(2'-hydroxyphenyl)-2-(4'-substituted benzylidine)-3-(4-nitrophenyl amino)thiazoloquinazolines (5a-j) were synthesized by the reported method and evaluated for their phosphodiesterase inhibitory activity. All test compounds exhibited good ...

A formal enantioselective synthesis of benazepril.HCl (4), an anti- hypertensive drug, is reported. Our synthesis employed an asymmetric aza-Michael addition of L-homophenylalanine ethyl ester (LHPE, 1) to 4-(2-nitrophenyl)-4-oxo- but-2-enoic acid methyl ester (6) as the key step to prepare (2S,3'S)-2-(2-oxo-2,3,4,5- tetrahydro-1H-benzo[b]azepin-3-ylamino)-4-phenylbutyric acid ethyl ester (8), ...

Anaerobically treated molasses-based distilleries spent wash is a major source of terrestrial and aquatic pollution due to the mixture various unknown organometallic compounds in discharged waste. The nature pollutants present effluent has be characterized prior evaluation their fate environment at tropic levels. absorption maxima (λmax) were obtained 295 nm which indicated that melanoidins are...

In this work, we present a study on series of recently synthesized indole derived compounds that were previously suggested by experimental tests as having herbicidal action. Density functional theory (DFT) and its time-dependent formalism (TD-DFT) used for investigating ground excited state properties, respectively. The M06-2X CAM-B3LYP exchange-correlation with the aug-cc-pVTZ basis set. Compu...

A series of novel mononuclear iron(III) complexes [Fe(saldpt)(atz)] (1) and [Fe(Rsalpet)(atz)] (2a-d) involving 5-aminotetrazole (Hatz) and pentadentate Schiff base ligands (H2saldpt = N,N'-bis(2-hydroxybenzyliden)-1,7-diamino-4-azaheptane, H2salpet = N,N'-bis(2-hydroxybenzyliden)-1,6-diamino-3-azahexane, H25Cl-salpet = N,N'-bis(5-chloro-2-hydroxybenzylidene)-1,6-diamino-3-azahexane, H25Br-salp...

A series of new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazine-2-thione (THTT) derivatives (4a-g) were prepared using a convenient and general one-pot procedure and evaluated for their in vitro antibacterial and antifungal activities by using the microdilution method in comparison with ampicillin and fluconazole. 3-Phenyl-5-(1-phenylethyl)-tetrahydro-2H-1,3,5-thiadiazine-2-thione (4a) and 3p...