The metabolism of 5-fluorouracil (511) in tumors and livers of RII -1 tumor-bearing C3H mice given i.p. injections of 5FU was serially moni tored by "F magnetic resonance spectroscopy. The levels of 5FU and fluoronucleotide detected in the tumors after a dose of 130 mg/kg (n = 13) »ereless than one-third of those after 260-mg/kg 5FU (n = 14). During the days after these doses, tumor size decre...

INTRODUCTION In an African setting surgery is generally accepted as the treatment of first choice for glaucoma. A problem with trabeculectomy surgery for the glaucomas is the frequent co-existence and exacerbation of cataract. We report a randomized controlled trial to compare the use of beta radiation with 5FU in combined cataract and glaucoma surgery. PARTICIPANTS AND METHODS Consenting adu...

Cytotoxic anticancer drugs can promote antitumor immune responses. The anticancer activity of 5-fluorouracil (5FU) relies on the restoration of T-cell immunity following the elimination of myeloid-derived suppressor cells (MDSCs). We have recently discovered that the 5FU-driven activation of the NLRP3 inflammasome in MDSCs promotes tumor angiogenesis by eliciting TH17 responses that compromise ...

BACKGROUND The aim was to determine the maximum tolerable dose of oxaliplatin added to (oral) 5FU in irresectable rectal cancer. PATIENTS AND METHODS Nineteen patients were treated; 13 patients received 5FU/LV and 6 patients capecitabine. Oxaliplatin was administered on days 1 and 29 at dose levels 85 and 130 mg/m2. Four to seven weeks thereafter, surgery was performed. RESULTS In 6 patient...

New nonstoichiometric polyelectrolyte complex nanoparticles were prepared based on chitosan (CS) and polyaspartic acid sodium salt (PAsp). The physicochemical properties of the complexes were investigated by means of turbidity, dynamic light scattering, transmission electron microscopy and zeta potential. The results indicated that the slow dropwise addition of chitosan into PAsp allowed to ela...

Encouraged by preclinical synergism between docetaxel and 5-fluorouracil (5FU), we conducted a Phase I study of docetaxel in combination with continuous i.v. infusion of 5FU in patients with advanced solid tumors to determine the maximum tolerated dose, the recommended dose for Phase II studies, and the safety and pharmacokinetic profiles of this combination. Forty-two patients with advanced so...

3535 Background: Potential advantages of preoperative radiotherapy (RT) include increased resectability, sphincter preservation, local control, and overall survival. This randomized phase II study was designed to evaluate, pathologic complete response(pCR) to preoperative combined-modality chemotherapy with 5-fluorouracil (5FU) and RT, or with 5FU, irinotecan (I) and RT in patients with adenoca...

Background: Hand-Foot Syndrome (HFS) is a dermatological toxicity induced by capecitabine (CAP)/fluorouracil (5FU). HFS related to damage of palmar/plantar epidermal/dermal cells 5FU, and inflammation-mediated cyclooxygenase-2 pathways. We hypothesize applying OQL036 topical gel prodrug metabolizing thymidine (TdR) naproxen (NAP) may alleviate associated with CAP/5FU. Methods: To test the prote...

Our aim was to decipher the role and clinical relevance of the YAP/TAZ transcriptional coactivators in the regulation of the proliferation/quiescence balance in human colon cancer cells (CCC) and survival after 5FU-based chemotherapy. The prognostic value of YAP/TAZ on tumor relapse and overall survival was assessed in a five-year follow-up study using specimens of liver metastases (n = 70) fro...

Amplification of human epidermal growth factor receptor 2 (HER2) has been detected in 20% to 30% of gastric cancers and is associated with a poor outcome. Combination therapies with HER2-targeting agents and cytotoxic agents are considered a potential therapeutic option for gastric cancer with HER2 amplification. We have now investigated the effects of combination treatment with the oral fluoro...