food borne viral infections are recognized increasingly as human illneses. hepatitis a virus (hav) is an important pathogen which has been responsible for water and many food – borne outbreeks especially milk . in this study for approaching to best diagnosis method of hav in milk by elisa technique, various dilutions of hav antigen (1 ml/l, 10-3 ml/l, 10-6 ml/l, 10-9 ml/l) were added to uht mil...

Abstract We engineered a novel adenovirus with modified capsid for use as an integrated anticancer gene therapy and to circumvent pre-existing immunity. The adenovirus, SynBAd, when administered intravenously, induced antigen-specific CD8 T cell immunity in the liver of mice (C57BL/6) splenic population effector memory cells at levels equivalent those by human Adenovirus serotype 5 (Ad5). Altho...

objective: hepatitis c virus (hcv) is one of the most relevant persistent infections afflicting the human population. control of viral replication in hcv infection has been associated with the cellular component of the host immune response. several mechanisms have been proposed to explain this abnormal immune response, among them an altered activity of regulatory t cells (tregs) being the most ...

Different antigens of Pasteurella multocida Carter's type 6:B including whole bacterium, antigen heated at 56 degrees C, antigen heated at 100 degrees C, sonicated antigen, capsular antigen, potassium thiocyanate extract, lipopolysaccharide and sodium salicylate extract were evaluated to assess protection in buffalo calves against haemorrhagic septicaemia. Sera from calves with known protection...

To elucidate mechanisms underlying neuroprotective properties of astrocytes in brain ischemia, production of neurotrophic mediators was studied in astrocytes exposed to hypoxia/reoxygenation (H/R). Rat astrocytes subjected to H/R released increased amounts of interleukin (IL) 6 in a time-dependent manner, whereas levels of tumor necrosis factor and IL-1 remained undetectable. IL-6 transcripts w...

We characterize the nature and regulation of a human neutrophil cell surface antigen recognized by monoclonal antibodies (the DREG series) against a human lymphocyte peripheral lymph node homing receptor. Human neutrophils express high levels of the DREG antigen, whose expression is downregulated after treatment with phorbol myristate acetate, or the chemotactic factors C5a and FMLP. Interestin...

A temperate phage, designated Sf6, has been isolated from Shigella flexneri 3a. Characterization of Sf6 revealed that it possesses the capacity for converting the S. flexneri 3,4 group antigen complex to group factor 6. Serological studies and chemical analysis of lipopolysaccharide from converted strains suggest that group factor 6 is a reflection of an acetylation of the preexisting 3,4 antig...