Unsaturated fatty acids (UFAs), such as omega-3 and omega-6 poly- and omega-9 monounsaturated fatty acids are important nutrients and major components of neuronal cell membranes. They play a major role in modulating brain functions and physiology and may therefore diminish behavioral and physiological stress reactions in corroboration with decreased cortisol concentrations. Functionally, cortis...

We recently showed that treatment of macrophages prior to Mycobacterium tuberculosis infection with the pro-inflammatory omega-6 lipid, arachidonic acid (AA) enhanced bacterial killing whereas the anti-inflammatory, omega-3 lipid eicosapentaenoic acid (EPA) stimulated bacterial growth. Here we tested if these effects were depending on when lipids were added to macrophages: before or during Myco...

OBJECTIVE The aim of the study was to assess omega 3/6 fatty acids (eye q) in attention deficit hyperactivity disorder (ADHD). METHOD The study included a randomized, 3-month, omega 3/6 placebo-controlled, one-way crossover trial with 75 children and adolescents (8-18 years), followed by 3 months with omega 3/6 for all. Investigator-rated ADHD Rating Scale-IV and Clinical Global Impression (C...

OBJECTIVE To study the effects of polyunsaturated fatty acids (PUFA) omega-3 and omega-6 in the oxidative stress and in liver regeneration in rats subjected to 70% partial hepatectomy (PH, 70% hepatectomy, Higgins-Anderson partial hepatectomy). METHODS 72 young male Wistar rats were randomly divided into four equal-sized groups: control (G1), partially hepatectomized (G2), partially hepatecto...

the aim of this study was to evaluate the effect of glycogenic diets supplemented with different poly unsaturated fatty acids on reproductive performance of iran black ewes in two different managing programs. ewes were allocated in two different groups; group a (n = 75) and group b (n = 25). ewes from group a were stopped from suckling followed by introducing to the rams on days 80 and 90, resp...

Several sources of information suggest that human beings evolved on a diet with a ratio of omega-6 to omega-3 essential fatty acids (EFA) of approximately 1 whereas in Western diets the ratio is 15/1-16.7/1. Western diets are deficient in omega-3 fatty acids, and have excessive amounts of omega-6 fatty acids compared with the diet on which human beings evolved and their genetic patterns were es...

OBJECTIVE To assess the effect of food containing high concentrations of fish oil omega-3 fatty acids and a low omega-6-omega-3 fatty acid ratio on clinical signs of osteoarthritis in dogs. DESIGN Randomized, double-blinded, controlled clinical trial. ANIMALS 127 client-owned dogs with osteoarthritis in 1 or more joints from 18 privately owned veterinary clinics. PROCEDURES Dogs were rand...